Neutralization-sensitive epitopes are conserved among geographically diverse isolates of Cryptosporidium parvum

E. W. Uhl, R. M. O'Connor, L. E. Perryman, M. W. Riggs

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Isolates of Cryptosporidium parvum from New York, Florida, Brazil, Mexico, and Peru were examined for the presence of two sporozoite surface epitopes originally identified in an Iowa isolate by neutralizing monoclonal antibodies (MAbs) 18.44 and 17.41. Immunofluorescence microscopy and immunoblotting demonstrated the presence of both epitopes on all isolates. Incubation of DEAE-cellulose-purified sporozoites of the New York, Florida, Brazil, and Mexico isolates with MAb 18.44 or 17.41 significantly neutralized their infectivity for 4- to 6-day-old BALB/c mice. The results indicate that two neutralization-sensitive epitopes are conserved on geographically diverse C. parvum isolates.

Original languageEnglish (US)
Pages (from-to)1703-1706
Number of pages4
JournalInfection and Immunity
Volume60
Issue number4
StatePublished - 1992

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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