Neutropenia and fever in patients undergoing combination chemotherapy for malignant germ cell tumors of the ovary

Setsuko K Chambers, P. E. Schwartz

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Fifteen neutropenic febrile episodes occurred in 29 patients undergoing chemotherapy for malignant germ cell tumors of the ovary. Vincristine, actinomycin-D, and cyclophosphamide were used in 24 patients; cis-diamminedichloroplatinum, vinblastine, and bleomycin in three; and both regimens in two. All 15 patients were treated with antibiotic combinations (gentamicin and clindamycin in 12 cases), usually until neutropenia resolved. The mean nadir total granulocyte count was 123/mm3. There was no septicemia or drug-related deaths. With reduction in chemotherapy dosage, 87% of patients tolerated subsequent courses. The survival rates in this disease are excellent, although toxicity is substantial from both regimens. These neutropenic febrile episodes can be managed successfully without interrupting chemotherapy.

Original languageEnglish (US)
Pages (from-to)842-846
Number of pages5
JournalObstetrics and Gynecology
Volume68
Issue number6
StatePublished - 1986
Externally publishedYes

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Germ Cell and Embryonal Neoplasms
Combination Drug Therapy
Neutropenia
Ovary
Fever
Drug Therapy
Clindamycin
Vinblastine
Dactinomycin
Vincristine
Gentamicins
Granulocytes
Cyclophosphamide
Cisplatin
Sepsis
Survival Rate
Anti-Bacterial Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Neutropenia and fever in patients undergoing combination chemotherapy for malignant germ cell tumors of the ovary. / Chambers, Setsuko K; Schwartz, P. E.

In: Obstetrics and Gynecology, Vol. 68, No. 6, 1986, p. 842-846.

Research output: Contribution to journalArticle

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