Abstract
Phase I and II studies have been conducted with various combinations of vincristine, bleomycin, methyl-CCNU, and cyclophosphamide in the treatment of bronchogenic carcinoma. Although bleomycin alone was not very active, the combination of vincristine and bleomycin produced three partial responses in 12 patients. Methyl-CCNU alone produced four partial responses in 16 patients, whereas the combination of methyl-CCNU and cyclophosphamide produced three partial responses in ten patients. Preliminary studies have been initiated with the four drugs in combination and five of 13 patients have achieved partial responses. Major toxic effects have included nausea, vomiting, skin changes, neuropathy, and myelosuppression. Further studies with this combination are warranted.
| Original language | English (US) |
|---|---|
| Title of host publication | CANCER CHEMOTHER.REP. |
| Volume | 4 |
| Edition | 2 |
| State | Published - 1973 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
New agents and combinations in the treatment of bronchogenic carcinoma. / Bodey, G. P.; Gottlieb, J. A.; Livingston, Robert B; Frei, E.
CANCER CHEMOTHER.REP.. Vol. 4 2. ed. 1973.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - New agents and combinations in the treatment of bronchogenic carcinoma
AU - Bodey, G. P.
AU - Gottlieb, J. A.
AU - Livingston, Robert B
AU - Frei, E.
PY - 1973
Y1 - 1973
N2 - Phase I and II studies have been conducted with various combinations of vincristine, bleomycin, methyl-CCNU, and cyclophosphamide in the treatment of bronchogenic carcinoma. Although bleomycin alone was not very active, the combination of vincristine and bleomycin produced three partial responses in 12 patients. Methyl-CCNU alone produced four partial responses in 16 patients, whereas the combination of methyl-CCNU and cyclophosphamide produced three partial responses in ten patients. Preliminary studies have been initiated with the four drugs in combination and five of 13 patients have achieved partial responses. Major toxic effects have included nausea, vomiting, skin changes, neuropathy, and myelosuppression. Further studies with this combination are warranted.
AB - Phase I and II studies have been conducted with various combinations of vincristine, bleomycin, methyl-CCNU, and cyclophosphamide in the treatment of bronchogenic carcinoma. Although bleomycin alone was not very active, the combination of vincristine and bleomycin produced three partial responses in 12 patients. Methyl-CCNU alone produced four partial responses in 16 patients, whereas the combination of methyl-CCNU and cyclophosphamide produced three partial responses in ten patients. Preliminary studies have been initiated with the four drugs in combination and five of 13 patients have achieved partial responses. Major toxic effects have included nausea, vomiting, skin changes, neuropathy, and myelosuppression. Further studies with this combination are warranted.
UR - http://www.scopus.com/inward/record.url?scp=0015788519&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015788519&partnerID=8YFLogxK
M3 - Chapter
C2 - 4125740
AN - SCOPUS:0015788519
VL - 4
BT - CANCER CHEMOTHER.REP.
ER -