New agents and combinations in the treatment of bronchogenic carcinoma

G. P. Bodey, J. A. Gottlieb, Robert B Livingston, E. Frei

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Phase I and II studies have been conducted with various combinations of vincristine, bleomycin, methyl-CCNU, and cyclophosphamide in the treatment of bronchogenic carcinoma. Although bleomycin alone was not very active, the combination of vincristine and bleomycin produced three partial responses in 12 patients. Methyl-CCNU alone produced four partial responses in 16 patients, whereas the combination of methyl-CCNU and cyclophosphamide produced three partial responses in ten patients. Preliminary studies have been initiated with the four drugs in combination and five of 13 patients have achieved partial responses. Major toxic effects have included nausea, vomiting, skin changes, neuropathy, and myelosuppression. Further studies with this combination are warranted.

Original languageEnglish (US)
Title of host publicationCANCER CHEMOTHER.REP.
Volume4
Edition2
StatePublished - 1973
Externally publishedYes

Fingerprint

Semustine
Bronchogenic Carcinoma
Bleomycin
Vincristine
Cyclophosphamide
Poisons
Drug Combinations
Therapeutics
Nausea
Vomiting
Skin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bodey, G. P., Gottlieb, J. A., Livingston, R. B., & Frei, E. (1973). New agents and combinations in the treatment of bronchogenic carcinoma. In CANCER CHEMOTHER.REP. (2 ed., Vol. 4)

New agents and combinations in the treatment of bronchogenic carcinoma. / Bodey, G. P.; Gottlieb, J. A.; Livingston, Robert B; Frei, E.

CANCER CHEMOTHER.REP.. Vol. 4 2. ed. 1973.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bodey, GP, Gottlieb, JA, Livingston, RB & Frei, E 1973, New agents and combinations in the treatment of bronchogenic carcinoma. in CANCER CHEMOTHER.REP.. 2 edn, vol. 4.
Bodey GP, Gottlieb JA, Livingston RB, Frei E. New agents and combinations in the treatment of bronchogenic carcinoma. In CANCER CHEMOTHER.REP.. 2 ed. Vol. 4. 1973
Bodey, G. P. ; Gottlieb, J. A. ; Livingston, Robert B ; Frei, E. / New agents and combinations in the treatment of bronchogenic carcinoma. CANCER CHEMOTHER.REP.. Vol. 4 2. ed. 1973.
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