New approaches for the treatment of pain: The GDNF family of neurotrophic growth factors

Dinah W Y Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian, Frank Porreca

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalCurrent Topics in Medicinal Chemistry
Volume5
Issue number6
DOIs
StatePublished - 2005

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Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factors
Intercellular Signaling Peptides and Proteins
Ligands
Pain
Peripheral Nerve Injuries
Neuralgia
Therapeutics
Bioactivity
Modulation
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)
  • Chemistry(all)

Cite this

New approaches for the treatment of pain : The GDNF family of neurotrophic growth factors. / Sah, Dinah W Y; Ossipov, Michael H.; Rossomando, Anthony; Silvian, Laura; Porreca, Frank.

In: Current Topics in Medicinal Chemistry, Vol. 5, No. 6, 2005, p. 577-583.

Research output: Contribution to journalArticle

Sah, Dinah W Y ; Ossipov, Michael H. ; Rossomando, Anthony ; Silvian, Laura ; Porreca, Frank. / New approaches for the treatment of pain : The GDNF family of neurotrophic growth factors. In: Current Topics in Medicinal Chemistry. 2005 ; Vol. 5, No. 6. pp. 577-583.
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