New approaches for the treatment of pain: The GDNF family of neurotrophic growth factors

Dinah W.Y. Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian, Frank Porreca

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

Original languageEnglish (US)
Pages (from-to)577-583
Number of pages7
JournalCurrent topics in medicinal chemistry
Volume5
Issue number6
DOIs
StatePublished - Aug 8 2005

ASJC Scopus subject areas

  • Drug Discovery

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