### Abstract

In a pure estimation task, a signal is known to be present, and we wish to determine numerical values for parameters that describe it. We compared the performance of the classical Wiener estimator and a new scanning-linear estimator for the task of estimating signal location, signal volume, and signal amplitude from noisy image data. Both procedures incorporate prior knowledge of the data's statistical fluctuations and minimize a given metric of error. First we explore the classical Wiener estimator, which operates linearly on the data and minimizes .the ensemble mean-squared error among linear methods. The signal is embedded in random background to simulate the effect of nuisance parameters. The results of our performance tests indicate the Wiener estimator is fundamentally unable to locate a signal, regardless of the quality of the image, when the background is random. Even when the simulated relationship between the object and image was reduced to noisy samples of planar objects, linear operations on.the data failed to locate the signal. Given these new results on the fundamental limitations of Wiener estimation, we extend our methods to include more complex data processing. We introduce and evaluate a scanninglinear estimator that performs impressively. The scanning action of the estimator refers to seeking a solution that maximizes a linear metric, thereby requiring a global-extremum search. The linear metric to be optimized can be derived as a special case of maximum a posteriori (MAP) estimation when the likelihood is Gaussian and a slowly-varying covariance approximation is made.

Original language | English (US) |
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Title of host publication | IEEE Nuclear Science Symposium Conference Record |

Pages | 4328-4330 |

Number of pages | 3 |

DOIs | |

State | Published - 2008 |

Event | 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany Duration: Oct 19 2008 → Oct 25 2008 |

### Other

Other | 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 |
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Country | Germany |

City | Dresden |

Period | 10/19/08 → 10/25/08 |

### Fingerprint

### Keywords

- Assessment of image quality
- Estimation
- SPECT

### ASJC Scopus subject areas

- Radiation
- Nuclear and High Energy Physics
- Radiology Nuclear Medicine and imaging

### Cite this

*IEEE Nuclear Science Symposium Conference Record*(pp. 4328-4330). [4774241] https://doi.org/10.1109/NSSMIC.2008.4774241

**New approaches to parameter estimation from noisy image data.** / Kupinski, Meridith Kathryn; Clarkson, Eric W; Barrett, Harrison H.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

*IEEE Nuclear Science Symposium Conference Record.*, 4774241, pp. 4328-4330, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774241

}

TY - GEN

T1 - New approaches to parameter estimation from noisy image data

AU - Kupinski, Meridith Kathryn

AU - Clarkson, Eric W

AU - Barrett, Harrison H

PY - 2008

Y1 - 2008

N2 - In a pure estimation task, a signal is known to be present, and we wish to determine numerical values for parameters that describe it. We compared the performance of the classical Wiener estimator and a new scanning-linear estimator for the task of estimating signal location, signal volume, and signal amplitude from noisy image data. Both procedures incorporate prior knowledge of the data's statistical fluctuations and minimize a given metric of error. First we explore the classical Wiener estimator, which operates linearly on the data and minimizes .the ensemble mean-squared error among linear methods. The signal is embedded in random background to simulate the effect of nuisance parameters. The results of our performance tests indicate the Wiener estimator is fundamentally unable to locate a signal, regardless of the quality of the image, when the background is random. Even when the simulated relationship between the object and image was reduced to noisy samples of planar objects, linear operations on.the data failed to locate the signal. Given these new results on the fundamental limitations of Wiener estimation, we extend our methods to include more complex data processing. We introduce and evaluate a scanninglinear estimator that performs impressively. The scanning action of the estimator refers to seeking a solution that maximizes a linear metric, thereby requiring a global-extremum search. The linear metric to be optimized can be derived as a special case of maximum a posteriori (MAP) estimation when the likelihood is Gaussian and a slowly-varying covariance approximation is made.

AB - In a pure estimation task, a signal is known to be present, and we wish to determine numerical values for parameters that describe it. We compared the performance of the classical Wiener estimator and a new scanning-linear estimator for the task of estimating signal location, signal volume, and signal amplitude from noisy image data. Both procedures incorporate prior knowledge of the data's statistical fluctuations and minimize a given metric of error. First we explore the classical Wiener estimator, which operates linearly on the data and minimizes .the ensemble mean-squared error among linear methods. The signal is embedded in random background to simulate the effect of nuisance parameters. The results of our performance tests indicate the Wiener estimator is fundamentally unable to locate a signal, regardless of the quality of the image, when the background is random. Even when the simulated relationship between the object and image was reduced to noisy samples of planar objects, linear operations on.the data failed to locate the signal. Given these new results on the fundamental limitations of Wiener estimation, we extend our methods to include more complex data processing. We introduce and evaluate a scanninglinear estimator that performs impressively. The scanning action of the estimator refers to seeking a solution that maximizes a linear metric, thereby requiring a global-extremum search. The linear metric to be optimized can be derived as a special case of maximum a posteriori (MAP) estimation when the likelihood is Gaussian and a slowly-varying covariance approximation is made.

KW - Assessment of image quality

KW - Estimation

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=67649172536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649172536&partnerID=8YFLogxK

U2 - 10.1109/NSSMIC.2008.4774241

DO - 10.1109/NSSMIC.2008.4774241

M3 - Conference contribution

SN - 9781424427154

SP - 4328

EP - 4330

BT - IEEE Nuclear Science Symposium Conference Record

ER -