New developments in the pathogenesis of smoke inhalation-induced pulmonary edema

M. L. Witten, Stuart F Quan, R>E Sobonya, R. J. Lemen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Smoke inhalation causes most of the deaths in the fire-related injuries, with pulmonary edema as a major determinant in the outcome of smoke-inhalation injury. The pathophysiology of pulmonary edema is thought to be related to the products of incomplete combustion. Damage to the integrity of the alveolar epithelium is one of the determinants of the development of smoke-induced pulmonary edema. In recent studies using lung clearance of aerosolized pentetic acid (DTPA [diethylenetriaminepentaacetic acid]) labeled with technetium Tc 99m to assess the permeability of the alveolar epithelium, several factors were identified that may increase a person's susceptibility to smoke-induced acute lung injury. These are increased initial alveolar permeability and alterations in the number and activity of alveolar macrophages. Clinical measurement of 99m TcDTPA clearance may provide a sensitive and convenient method for the early detection and serial assessment of smoke-induced alveolar epithelial permeability changes.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalWestern Journal of Medicine
Volume148
Issue number1
StatePublished - 1988

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Pulmonary Edema
Smoke
Inhalation
Permeability
Smoke Inhalation Injury
Epithelium
Pentetic Acid
Acute Lung Injury
Technetium
Alveolar Macrophages
Cause of Death
Lung
Acids
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New developments in the pathogenesis of smoke inhalation-induced pulmonary edema. / Witten, M. L.; Quan, Stuart F; Sobonya, R>E; Lemen, R. J.

In: Western Journal of Medicine, Vol. 148, No. 1, 1988, p. 33-36.

Research output: Contribution to journalArticle

Witten, M. L. ; Quan, Stuart F ; Sobonya, R>E ; Lemen, R. J. / New developments in the pathogenesis of smoke inhalation-induced pulmonary edema. In: Western Journal of Medicine. 1988 ; Vol. 148, No. 1. pp. 33-36.
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