New hirsutane based sesquiterpenes from salt water cultures of a marine sponge-derived fungus and the terrestrial fungus Coriolus consors

Gui Yang Sheng Wang, Leif M. Abrell, Abigail Avelar, Bethel M. Borgeson, Phillip Crews

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Five new cyclic sesquiterpenes, hirsutanols A (6), B (7), C (8), hirsutanol D (9), and ent-gloeosteretriol (10) and a new diketopiperazine (14) were isolated from salt water cultures of two fungi. Seaquiterpenes 6 - 8 and 10 were obtained from an unidentified fungus separated from an Indo- Pacific sponge Haliclona sp. while 9 and 14 were produced by the terrestrial fungus Coriolus consors cultured under both sea water and deionized water media. Hirsutanol A (6) and ent-gloeosteretriol (10) were found to be anti- microbial (Bacillus subtilus) active. All structures were elucidated by spectroscopic methods.

Original languageEnglish (US)
Pages (from-to)7335-7342
Number of pages8
JournalTetrahedron
Volume54
Issue number26
DOIs
StatePublished - Jun 25 1998

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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