New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens

Stephanie H. Tolbert, Peter D. McFadden, Douglas A Loy

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol % salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol % of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal). Particles based on a new curcuminoid-bridged monomer were also prepared (B-Curc). Sunscreen leaching, photodegradation, and sunscreen performance were determined for the E-Sal, cap-E-Sal, P-Sal, B-Sal, and B-Curc particles. Covalent attachment, particularly with bridged sunscreen monomers, reduced leaching and photodegradation over physical encapsulation, even with capping.

Original languageEnglish (US)
Pages (from-to)3160-3174
Number of pages15
JournalACS Applied Materials and Interfaces
Volume8
Issue number5
DOIs
StatePublished - Feb 17 2016

Fingerprint

Sun hoods
Silicon Dioxide
Silica
Salicylates
Encapsulation
2-ethylhexyl salicylate
Monomers
Photodegradation
Leaching
polysilsesquioxane
Microemulsions
Oils
Polymerization
Nanoparticles
Degradation
Water

Keywords

  • hybrid organic inorganic particles
  • pendant versus bridged polysilsesquioxanes
  • sunscreen

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens. / Tolbert, Stephanie H.; McFadden, Peter D.; Loy, Douglas A.

In: ACS Applied Materials and Interfaces, Vol. 8, No. 5, 17.02.2016, p. 3160-3174.

Research output: Contribution to journalArticle

Tolbert, Stephanie H. ; McFadden, Peter D. ; Loy, Douglas A. / New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens. In: ACS Applied Materials and Interfaces. 2016 ; Vol. 8, No. 5. pp. 3160-3174.
@article{e3817cf8f9c54570a809e6b30a2d6414,
title = "New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens",
abstract = "Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol {\%} salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol {\%} of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal). Particles based on a new curcuminoid-bridged monomer were also prepared (B-Curc). Sunscreen leaching, photodegradation, and sunscreen performance were determined for the E-Sal, cap-E-Sal, P-Sal, B-Sal, and B-Curc particles. Covalent attachment, particularly with bridged sunscreen monomers, reduced leaching and photodegradation over physical encapsulation, even with capping.",
keywords = "hybrid organic inorganic particles, pendant versus bridged polysilsesquioxanes, sunscreen",
author = "Tolbert, {Stephanie H.} and McFadden, {Peter D.} and Loy, {Douglas A}",
year = "2016",
month = "2",
day = "17",
doi = "10.1021/acsami.5b10472",
language = "English (US)",
volume = "8",
pages = "3160--3174",
journal = "ACS applied materials & interfaces",
issn = "1944-8244",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - New Hybrid Organic/Inorganic Polysilsesquioxane-Silica Particles as Sunscreens

AU - Tolbert, Stephanie H.

AU - McFadden, Peter D.

AU - Loy, Douglas A

PY - 2016/2/17

Y1 - 2016/2/17

N2 - Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol % salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol % of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal). Particles based on a new curcuminoid-bridged monomer were also prepared (B-Curc). Sunscreen leaching, photodegradation, and sunscreen performance were determined for the E-Sal, cap-E-Sal, P-Sal, B-Sal, and B-Curc particles. Covalent attachment, particularly with bridged sunscreen monomers, reduced leaching and photodegradation over physical encapsulation, even with capping.

AB - Effectiveness of organic sunscreens is limited by phototoxicity and degradation. Both of which can be significantly reduced by encapsulation in hollow particles or covalent incorporation into the solid structure of particles, but direct comparisons of the two methods have not been reported. In this study, physical encapsulation and covalent incorporation of sunscreens were compared with 1 mol % salicylate and curcumeroid sunscreens. 2-Ethylhexyl salicylate was physically encapsulated in hollow silica nanoparticles prepared by oil-in-water (O/W) microemulsion polymerizations (E-Sal). Some of these particles were coated with an additional shell or cap of silica to reduce leaking of sunscreen (cap-E-Sal). Covalent incorporation involved co-polymerizing tetraethoxysilane (TEOS) with 0.2 mol % of new salicylate and curcuminoid sunscreen monomers with triethoxsilyl groups. Particles were prepared with the salicylate attached to the silica matrix through single silsesquioxane groups (pendant; P-Sal) and two silsesquioxane groups (bridged; B-Sal). Particles based on a new curcuminoid-bridged monomer were also prepared (B-Curc). Sunscreen leaching, photodegradation, and sunscreen performance were determined for the E-Sal, cap-E-Sal, P-Sal, B-Sal, and B-Curc particles. Covalent attachment, particularly with bridged sunscreen monomers, reduced leaching and photodegradation over physical encapsulation, even with capping.

KW - hybrid organic inorganic particles

KW - pendant versus bridged polysilsesquioxanes

KW - sunscreen

UR - http://www.scopus.com/inward/record.url?scp=84958211689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958211689&partnerID=8YFLogxK

U2 - 10.1021/acsami.5b10472

DO - 10.1021/acsami.5b10472

M3 - Article

C2 - 26730573

AN - SCOPUS:84958211689

VL - 8

SP - 3160

EP - 3174

JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 5

ER -