Understanding the molecular mechanisms of glucocorticoid action is a primary step in the development of more effective therapeutic agents. An important part of the anti-inflammatory effects of glucocorticoids in asthma involves repression of the expression of inflammatory mediators, particularly cytokines. The NFκB and AP-1 transcription factors seem to be involved in the expression of a number of crucial target genes in asthma, and there are several possible mechanisms through which glucocorticoids may repress genes regulated by NFκB and AP-1. Recent studies also have demonstrated a significant role for steroid-nuclear receptor coactivators, histone acetylation, and chromatin structure in gene regulation. These newly described mechanisms of gene regulation are discussed in relation to the molecular basis of glucocorticoid action.
ASJC Scopus subject areas
- Immunology and Allergy