New insights into the molecular basis of glucocorticoid action

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Understanding the molecular mechanisms of glucocorticoid action is a primary step in the development of more effective therapeutic agents. An important part of the anti-inflammatory effects of glucocorticoids in asthma involves repression of the expression of inflammatory mediators, particularly cytokines. The NFκB and AP-1 transcription factors seem to be involved in the expression of a number of crucial target genes in asthma, and there are several possible mechanisms through which glucocorticoids may repress genes regulated by NFκB and AP-1. Recent studies also have demonstrated a significant role for steroid-nuclear receptor coactivators, histone acetylation, and chromatin structure in gene regulation. These newly described mechanisms of gene regulation are discussed in relation to the molecular basis of glucocorticoid action.

Original languageEnglish (US)
Pages (from-to)653-670
Number of pages18
JournalImmunology and Allergy Clinics of North America
Volume19
Issue number4
DOIs
StatePublished - 1999

Fingerprint

Glucocorticoids
Transcription Factor AP-1
Genes
Nuclear Receptor Coactivators
Asthma
Steroid Receptors
Acetylation
Histones
Chromatin
Anti-Inflammatory Agents
Cytokines
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

New insights into the molecular basis of glucocorticoid action. / Bloom, John W.

In: Immunology and Allergy Clinics of North America, Vol. 19, No. 4, 1999, p. 653-670.

Research output: Contribution to journalArticle

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