New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis

Qiang Ding, Tracy Luckhardt, Louise Hecker, Yong Zhou, Gang Liu, Veena B. Antony, Joao DeAndrade, Victor J. Thannickal

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

Idiopathic pulmonary fibrosis (IPF) is the most common and lethal of the idiopathic interstitial pneumonias. There are currently no effective pharmacological therapies approved for the treatment of IPF. Despite the focus on targeting fibrogenic pathways, recent clinical trials have been largely disappointing. Progress is being made in elucidating key cellular processes and molecular pathways critical to IPF pathogenesis, and this should facilitate the development of more effective therapeutics for this recalcitrant disease. Emerging pathobiological concepts include the role of aging and cellular senescence, oxidative stress, endoplasmic reticulum stress, cellular plasticity, microRNAs and mechanotransduction. Therapeutic approaches that target molecular pathways to modulate aberrant cellular phenotypes and promote tissue homeostasis in the lung must be developed. Heterogeneity in biological and clinical phenotypes of IPF warrants a personalized medicine approach to diagnosis and treatment of this lung disorder.

Original languageEnglish (US)
Pages (from-to)981-1001
Number of pages21
JournalDrugs
Volume71
Issue number8
DOIs
StatePublished - Jun 20 2011
Externally publishedYes

Keywords

  • Acetylcysteine
  • Anticoagulants
  • Azathioprine
  • Bosentan
  • Corticosteroids
  • Etanercept
  • Idiopathic-pulmonary-fibrosis
  • Imatinib
  • Interferon
  • Interferon-gamma
  • Oxygen
  • Pirfenidone
  • Prednisone
  • Sildenafil.

ASJC Scopus subject areas

  • Pharmacology (medical)

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  • Cite this

    Ding, Q., Luckhardt, T., Hecker, L., Zhou, Y., Liu, G., Antony, V. B., DeAndrade, J., & Thannickal, V. J. (2011). New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs, 71(8), 981-1001. https://doi.org/10.2165/11591490-000000000-00000