New multi-component reaction accessing 3-aminoimidazo[1,2-a]pyridines

John Schwerkoske, Thierry Masquelin, Tom Perun, Christopher Hulme

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The novel one step solution phase synthesis of an array of 3-aminoimidazo[1,2-a]pyridines is reported. Reactions were performed in methanol by mixing a α-amino-pyridine, aldehyde and trimethylsilylcyanide (TMSCN) to give the desired product. Mediated by microwave irradiation and catalyzed by scandium triflate, the methodology represents the first one pot preparation of 3-aminoimidazo[1,2-a]pyridines that avoids the use of an isonitrile and subsequent de-protection strategy. The reaction is an example of a formal three-centre-three-component multi-component reaction.

Original languageEnglish (US)
Pages (from-to)8355-8357
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number48
DOIs
StatePublished - Nov 28 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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