New PDMP analogues inhibit process outgrowth in an insect cell line

Jacob P. Slavish, Donna K. Friel, Lynne A. Oland, Robin Polt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

D-threo-1-Phenyl-2-aminodecanoyl-3-morpholinopropanol (D-threo-PDMP) has previously been shown to inhibit the biosynthesis of glycosphingolipids (GSLs) in mammals and mammalian cell lines by the inhibition of glucosylceramide synthase. New D-threo-PDMP analogues were synthesized from D-serine, and found to suppress neurite extension in an embryonic insect cell line from the moth Manduca sexta, and in explanted neural tissue from insect pupae. Inhibition occurred at lower concentrations than D-threo-PDMP. The observed suppression of neurite formation was found to be reversible after the removal of the compounds. Due to their small size and short life cycle, M. sexta is shown to be an ideal model organism for studies of GSL effects in cellular development, and for drug development studies.

Original languageEnglish (US)
Pages (from-to)1487-1490
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number6
DOIs
StatePublished - Mar 22 2004

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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