New scheme for polarimetric glucose sensing without polarizers

Amy M. Winkler, Garret T. Bonnema, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A detection scheme involving amplitude modulation was simulated, demonstrating sensitivity to clinically relevant glucose concentrations and an acceptable error due to time varying linear birefringence of the cornea using Clarke Error Grid Analysis.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7572
DOIs
StatePublished - 2010
EventOptical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics - San Francisco, CA, United States
Duration: Jan 25 2010Jan 26 2010

Other

OtherOptical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics
CountryUnited States
CitySan Francisco, CA
Period1/25/101/26/10

Fingerprint

polarizers
glucose
Glucose
Polarization
cornea
Cornea
Birefringence
Optical Rotation
polarization
Amplitude modulation
Aqueous Humor
Optical tomography
Optical Coherence Tomography
optical activity
Interferometers
Blood Glucose
blood
birefringence
Blood
Light

Keywords

  • Noninvasive glucose monitoring
  • Optical
  • Polarimetry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Winkler, A. M., Bonnema, G. T., & Barton, J. K. (2010). New scheme for polarimetric glucose sensing without polarizers. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7572). [757204] https://doi.org/10.1117/12.842482

New scheme for polarimetric glucose sensing without polarizers. / Winkler, Amy M.; Bonnema, Garret T.; Barton, Jennifer K.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7572 2010. 757204.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Winkler, AM, Bonnema, GT & Barton, JK 2010, New scheme for polarimetric glucose sensing without polarizers. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7572, 757204, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, San Francisco, CA, United States, 1/25/10. https://doi.org/10.1117/12.842482
Winkler AM, Bonnema GT, Barton JK. New scheme for polarimetric glucose sensing without polarizers. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7572. 2010. 757204 https://doi.org/10.1117/12.842482
Winkler, Amy M. ; Bonnema, Garret T. ; Barton, Jennifer K. / New scheme for polarimetric glucose sensing without polarizers. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7572 2010.
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