New scheme for polarimetric glucose sensing without polarizers

Amy M. Winkler, Garret T. Bonnema, Jennifer K. Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A detection scheme involving amplitude modulation was simulated, demonstrating sensitivity to clinically relevant glucose concentrations and an acceptable error due to time varying linear birefringence of the cornea using Clarke Error Grid Analysis.

Original languageEnglish (US)
Title of host publicationOptical Diagnostics and Sensing X
Subtitle of host publicationToward Point-of-Care Diagnostics
DOIs
StatePublished - May 7 2010
EventOptical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics - San Francisco, CA, United States
Duration: Jan 25 2010Jan 26 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7572
ISSN (Print)1605-7422

Other

OtherOptical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics
CountryUnited States
CitySan Francisco, CA
Period1/25/101/26/10

Keywords

  • Noninvasive glucose monitoring
  • Optical
  • Polarimetry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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