New serologic tests for early detection of coccidioidomycosis

John N Galgiani, Gregory M. Grace, Linda L. Lundergan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Arizona college students suspected of having recently acquired coccidioidomycosis were tested for anticoccidioidal antibodies and circulating fungal antigens using conventional antibody detection methods and new ELISA procedures. Of 233 patients with compatible symptoms, 26 had anticoccidioidal antibodies detected by conventional tests. ELISA detected antibodies in sera from 20 of these patients and also from another 25 patients. Patients with antibodies detected by either conventional or ELISA procedures were significantly more likely to have abnormal chest radiographs, elevated erythrocyte sedimentation rates, or absent upper respiratory symptoms than were other patients. Circulating antigen was found in sera from 35 patients, 33 of whom had no detectable anticoccidioidal antibodies at that time. Detectable antigen was noted frequently in sera obtained within the first month after the onset of symptoms and was infrequently detected later when more patients exhibited antibodies. These results indicate the feasibility of developing ELISA procedures using spherule-derived antigens for earlier detection of coccidioidal infections.

Original languageEnglish (US)
Pages (from-to)671-674
Number of pages4
JournalJournal of Infectious Diseases
Volume163
Issue number3
StatePublished - 1991

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Coccidioidomycosis
Serologic Tests
Antibodies
Enzyme-Linked Immunosorbent Assay
Antigens
Fungal Antigens
Serum
Blood Sedimentation
Thorax
Students
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

New serologic tests for early detection of coccidioidomycosis. / Galgiani, John N; Grace, Gregory M.; Lundergan, Linda L.

In: Journal of Infectious Diseases, Vol. 163, No. 3, 1991, p. 671-674.

Research output: Contribution to journalArticle

Galgiani, JN, Grace, GM & Lundergan, LL 1991, 'New serologic tests for early detection of coccidioidomycosis', Journal of Infectious Diseases, vol. 163, no. 3, pp. 671-674.
Galgiani, John N ; Grace, Gregory M. ; Lundergan, Linda L. / New serologic tests for early detection of coccidioidomycosis. In: Journal of Infectious Diseases. 1991 ; Vol. 163, No. 3. pp. 671-674.
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