New therapeutic options for actinic keratosis and basal cell carcinoma.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Actinic keratosis (AK) is a common premalignant skin lesion that is frequently treated by cryosurgery. Basal cell carcinoma is the most common malignancy of man, and early-stage lesions are usually cured via surgery. Advanced basal cell carcinoma may require more extensive surgery resulting in deformity, and many advanced lesions cannot be treated surgically. Several recent developments have improved therapeutic options for both conditions. Cryosurgery is still a mainstay of treatment for AK, but the introduction of effective topical agents, imiquimod cream and ingenol mebutate, has provided alternatives to cryosurgery. For advanced basal cell carcinoma, the small-molecule inhibitor vismodegib has proven to be an effective therapy for lesions that are not amenable to surgery and has demonstrated ability to achieve dramatic improvement in advanced, potentially disfiguring cancer. 2014 by Frontline Medical Communications Inc.

Original languageEnglish (US)
JournalSeminars in Cutaneous Medicine and Surgery
Volume33
Issue number4 Suppl
StatePublished - 2014
Externally publishedYes

Fingerprint

Actinic Keratosis
Cryosurgery
Basal Cell Carcinoma
HhAntag691
imiquimod
Aptitude
Neoplasms
Therapeutics
Communication
Skin

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

New therapeutic options for actinic keratosis and basal cell carcinoma. / Sligh, James E.

In: Seminars in Cutaneous Medicine and Surgery, Vol. 33, No. 4 Suppl, 2014.

Research output: Contribution to journalArticle

@article{d19adbcbb3c646b48e1ad9b1e4987897,
title = "New therapeutic options for actinic keratosis and basal cell carcinoma.",
abstract = "Actinic keratosis (AK) is a common premalignant skin lesion that is frequently treated by cryosurgery. Basal cell carcinoma is the most common malignancy of man, and early-stage lesions are usually cured via surgery. Advanced basal cell carcinoma may require more extensive surgery resulting in deformity, and many advanced lesions cannot be treated surgically. Several recent developments have improved therapeutic options for both conditions. Cryosurgery is still a mainstay of treatment for AK, but the introduction of effective topical agents, imiquimod cream and ingenol mebutate, has provided alternatives to cryosurgery. For advanced basal cell carcinoma, the small-molecule inhibitor vismodegib has proven to be an effective therapy for lesions that are not amenable to surgery and has demonstrated ability to achieve dramatic improvement in advanced, potentially disfiguring cancer. 2014 by Frontline Medical Communications Inc.",
author = "Sligh, {James E}",
year = "2014",
language = "English (US)",
volume = "33",
journal = "Seminars in Cutaneous Medicine and Surgery",
issn = "1085-5629",
publisher = "W.B. Saunders Ltd",
number = "4 Suppl",

}

TY - JOUR

T1 - New therapeutic options for actinic keratosis and basal cell carcinoma.

AU - Sligh, James E

PY - 2014

Y1 - 2014

N2 - Actinic keratosis (AK) is a common premalignant skin lesion that is frequently treated by cryosurgery. Basal cell carcinoma is the most common malignancy of man, and early-stage lesions are usually cured via surgery. Advanced basal cell carcinoma may require more extensive surgery resulting in deformity, and many advanced lesions cannot be treated surgically. Several recent developments have improved therapeutic options for both conditions. Cryosurgery is still a mainstay of treatment for AK, but the introduction of effective topical agents, imiquimod cream and ingenol mebutate, has provided alternatives to cryosurgery. For advanced basal cell carcinoma, the small-molecule inhibitor vismodegib has proven to be an effective therapy for lesions that are not amenable to surgery and has demonstrated ability to achieve dramatic improvement in advanced, potentially disfiguring cancer. 2014 by Frontline Medical Communications Inc.

AB - Actinic keratosis (AK) is a common premalignant skin lesion that is frequently treated by cryosurgery. Basal cell carcinoma is the most common malignancy of man, and early-stage lesions are usually cured via surgery. Advanced basal cell carcinoma may require more extensive surgery resulting in deformity, and many advanced lesions cannot be treated surgically. Several recent developments have improved therapeutic options for both conditions. Cryosurgery is still a mainstay of treatment for AK, but the introduction of effective topical agents, imiquimod cream and ingenol mebutate, has provided alternatives to cryosurgery. For advanced basal cell carcinoma, the small-molecule inhibitor vismodegib has proven to be an effective therapy for lesions that are not amenable to surgery and has demonstrated ability to achieve dramatic improvement in advanced, potentially disfiguring cancer. 2014 by Frontline Medical Communications Inc.

UR - http://www.scopus.com/inward/record.url?scp=84908511210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908511210&partnerID=8YFLogxK

M3 - Article

VL - 33

JO - Seminars in Cutaneous Medicine and Surgery

JF - Seminars in Cutaneous Medicine and Surgery

SN - 1085-5629

IS - 4 Suppl

ER -