Treatment of triisopropylsilyl enol ethers with PhIO/TMSN3/TEMPO (cat.) -45°C results in 1,2-bis-azidonation, which appears to occur through a radical addition process; the 1-azido group can be replaced by carbon nucleophiles such as allyl, methyl, cyano, acetylene and acetonyl.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1995|
ASJC Scopus subject areas
- Molecular Medicine