Nitric oxide has differential effects on currents in different subsets of Manduca sexta Antennal lobe neurons

Mark Higgins, Michael Miller, Alan Nighorn

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Nitric oxide has been shown to regulate many biological systems including olfaction. In the moth olfactory system nitric oxide is produced in the antennal lobe in response to odor stimulation and has complex effects on the activity of both projection neurons and local interneurons. To examine the cell autonomous effects of nitric oxide on these cells, we used patch-clamp recording in conjunction with pharmacological manipulation of nitric oxide to test the hypothesis that nitric oxide differentially regulates the channel properties of these different antennal lobe neuron subsets. We found that nitric oxide caused increasing inward currents in a subset of projection neurons while the effects on local neurons were variable but consistent within identifiable morphological subtypes.

Original languageEnglish (US)
Article numbere42556
JournalPloS one
Volume7
Issue number8
DOIs
StatePublished - Aug 3 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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