Nitroxyl (HNO): Chemistry, biochemistry, and pharmacology

Jon M. Fukuto, Christopher H. Switzer, Katrina M. Miranda, David A. Wink

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

Recent discoveries of novel and potentially important biological activity have spurred interest in the chemistry and biochemistry of nitroxyl (HNO). It has become clear that, among all the nitrogen oxides, HNO is unique in its chemistry and biology. Currently, the intimate chemical details of the biological actions of HNO are not well understood. Moreover, many of the previously accepted chemical properties of HNO have been recently revised, thus requiring reevaluation of possible mechanisms of biological action. Herein, we review these developments in HNO chemistry and biology.

Original languageEnglish (US)
Pages (from-to)335-355
Number of pages21
JournalAnnual Review of Pharmacology and Toxicology
Volume45
DOIs
StatePublished - Mar 2 2005

Keywords

  • Calcitonin gene-related peptide
  • Ischemia-reperfusion
  • Nitric oxide
  • Thiols

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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