[Nle4, D-Phe7]-α-MSH: A superpotent melanotropin with prolonged action on vertebrate chromatophores

Mac E. Hadley, John H. Mieyr, Brent E. Martin, Ana M. Ana, Victor J Hruby, Tomi K. Sawyer, Elaine A. Powers, K. Ranga Rao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

1. 1. The in vitro and in vivo reponses of integumental chromatophores to α-MSH and a related analogue, [Nle4, D-Phe7]-α-MSH, were studied in a number of vertebrate species: the teleost, Lebistes reticulatus; the amphibians. Rana pipiens, R. catesbeiana, Xenopus laevis. Bufo alvarius, and B. cognatus; the lizard, Anolis carolinensis; the rattlesnake, Crotalus atrox. 2. 2. The α-melanotropin analogue was a superpotent agonist in the in vitro frog (R. pipiens, R. catesbeiana) and lizard (A. carolinensis) skin bioassays. 3. 3. In all species studied, the analogue exhibited ultraprolonged melanotropic activity, both in vitro and in vivo. 4. 4. This melanotropin and related analogues should prove useful in the study of numerous physiological processes, particularly when prolonged melanotropic activity is desired.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalComparative Biochemistry and Physiology -- Part A: Physiology
Volume81
Issue number1
DOIs
StatePublished - 1985

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Chromatophores
Melanocyte-Stimulating Hormones
Vertebrates
Crotalus
Rana pipiens
Lizards
Poecilia
Bufonidae
Physiological Phenomena
Bioassay
Xenopus laevis
Amphibians
Biological Assay
Anura
Skin
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Biochemistry

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[Nle4, D-Phe7]-α-MSH : A superpotent melanotropin with prolonged action on vertebrate chromatophores. / Hadley, Mac E.; Mieyr, John H.; Martin, Brent E.; Ana, Ana M.; Hruby, Victor J; Sawyer, Tomi K.; Powers, Elaine A.; Rao, K. Ranga.

In: Comparative Biochemistry and Physiology -- Part A: Physiology, Vol. 81, No. 1, 1985, p. 1-6.

Research output: Contribution to journalArticle

Hadley, Mac E. ; Mieyr, John H. ; Martin, Brent E. ; Ana, Ana M. ; Hruby, Victor J ; Sawyer, Tomi K. ; Powers, Elaine A. ; Rao, K. Ranga. / [Nle4, D-Phe7]-α-MSH : A superpotent melanotropin with prolonged action on vertebrate chromatophores. In: Comparative Biochemistry and Physiology -- Part A: Physiology. 1985 ; Vol. 81, No. 1. pp. 1-6.
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AU - Rao, K. Ranga

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