NMDA receptor antagonism blocks experience-dependent expansion of hippocampal "place fields"

A. D. Ekstrom, J. Meltzer, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journalArticle

188 Scopus citations

Abstract

In agreement with theories of sequence learning, hippocampal place representations expand asymmetrically during repeated route following. This behaviorally induced, experience-dependent expression of neuronal plasticity was blocked by the NMDAR antagonist CPP, suggesting that it may result from the temporal asymmetry and associative properties of LTP. NMDAR antagonism, however, had no effect on the range of the progressive shift of firing phase of hippocampal cells, relative to the theta rhythm, as the rat traverses the cell's "place field." Thus, when place fields normally expand with experience, the relationship between firing phase and position is altered, as predicted by models that account for "phase precession" on the basis of asymmetry of synaptic connection strengths. These effects of CPP mimic changes that occur during normal aging, suggesting mechanisms by which sequence learning deficits may arise in aged animals.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalNeuron
Volume31
Issue number4
DOIs
StatePublished - Aug 30 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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