NMR elastometry of fluid membranes in the mesoscopic regime

Gary V. Martinez, Emily M. Dykstra, Silvia Lope-Piedrafita, Constantin Job, Michael F. Brown

Research output: Contribution to journalArticle

Abstract

In solid-state 2H NMR of fluid lipid bilayers, quasielastic deformations at MHz frequencies are detected as a square-law dependence of the nuclear spin-lattice (R(1Z)) relaxation rates and order parameters (S(CD)). The signature square-law slope is found to decrease progressively with the mole fraction of cholesterol and with the acyl chain length, due to a stiffening of the membrane. The correspondence to thermal vesicle fluctuations and molecular dynamics simulations implies that a broad distribution of modes is present, ranging from the membrane size down to the molecular dimensions.

Original languageEnglish (US)
Pages (from-to)50902
Number of pages1
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume66
Issue number5
StatePublished - Nov 1 2002

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Membrane
membranes
Fluid
Lipid Bilayer
nuclear magnetic resonance
stiffening
Cholesterol
mole
Membranes
fluids
cholesterol
Vesicles
Lipid Bilayers
Molecular Dynamics Simulation
nuclear spin
Order Parameter
lipids
Slope
Signature
Correspondence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

NMR elastometry of fluid membranes in the mesoscopic regime. / Martinez, Gary V.; Dykstra, Emily M.; Lope-Piedrafita, Silvia; Job, Constantin; Brown, Michael F.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 66, No. 5, 01.11.2002, p. 50902.

Research output: Contribution to journalArticle

Martinez, GV, Dykstra, EM, Lope-Piedrafita, S, Job, C & Brown, MF 2002, 'NMR elastometry of fluid membranes in the mesoscopic regime', Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, vol. 66, no. 5, pp. 50902.
Martinez, Gary V. ; Dykstra, Emily M. ; Lope-Piedrafita, Silvia ; Job, Constantin ; Brown, Michael F. / NMR elastometry of fluid membranes in the mesoscopic regime. In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2002 ; Vol. 66, No. 5. pp. 50902.
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