No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)

D. C. Muller, A. M. Hodge, A. Fanidi, D. Albanes, X. M. Mai, X. O. Shu, S. J. Weinstein, T. L. Larose, X. Zhang, J. Han, M. J. Stampfer, S. A. Smith-Warner, J. Ma, J. M. Gaziano, H. D. Sesso, V. L. Stevens, M. L. McCullough, T. M. Layne, R. Prentice, M. PettingerCynthia Thomson, W. Zheng, Y. T. Gao, N. Rothman, Y. B. Xiang, H. Cai, R. Wang, J. M. Yuan, W. P. Koh, L. M. Butler, Q. Cai, W. J. Blot, J. Wu, P. M. Ueland, O. Midttun, A. Langhammer, K. Hveem, M. Johansson, J. Hultdin, K. Grankvist, A. A. Arslan, L. Le Marchand, G. Severi, M. Johansson, Paul Brennan

Research output: Contribution to journalArticle

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Abstract

Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.

Original languageEnglish (US)
Pages (from-to)1468-1475
Number of pages8
JournalAnnals of Oncology
Volume29
Issue number6
DOIs
StatePublished - Jun 1 2018

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Vitamin D
Lung Neoplasms
Prospective Studies
25-Hydroxyvitamin D 2
Smoking
Odds Ratio
Confidence Intervals
Calcifediol
Tandem Mass Spectrometry
Liquid Chromatography
Histology
Logistic Models

Keywords

  • Case-control
  • Consortium
  • Lung cancer
  • Prospective
  • Serum 25-hydroxyvitamin D
  • Vitamin D

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

No association between circulating concentrations of vitamin D and risk of lung cancer : An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). / Muller, D. C.; Hodge, A. M.; Fanidi, A.; Albanes, D.; Mai, X. M.; Shu, X. O.; Weinstein, S. J.; Larose, T. L.; Zhang, X.; Han, J.; Stampfer, M. J.; Smith-Warner, S. A.; Ma, J.; Gaziano, J. M.; Sesso, H. D.; Stevens, V. L.; McCullough, M. L.; Layne, T. M.; Prentice, R.; Pettinger, M.; Thomson, Cynthia; Zheng, W.; Gao, Y. T.; Rothman, N.; Xiang, Y. B.; Cai, H.; Wang, R.; Yuan, J. M.; Koh, W. P.; Butler, L. M.; Cai, Q.; Blot, W. J.; Wu, J.; Ueland, P. M.; Midttun, O.; Langhammer, A.; Hveem, K.; Johansson, M.; Hultdin, J.; Grankvist, K.; Arslan, A. A.; Le Marchand, L.; Severi, G.; Johansson, M.; Brennan, Paul.

In: Annals of Oncology, Vol. 29, No. 6, 01.06.2018, p. 1468-1475.

Research output: Contribution to journalArticle

Muller, DC, Hodge, AM, Fanidi, A, Albanes, D, Mai, XM, Shu, XO, Weinstein, SJ, Larose, TL, Zhang, X, Han, J, Stampfer, MJ, Smith-Warner, SA, Ma, J, Gaziano, JM, Sesso, HD, Stevens, VL, McCullough, ML, Layne, TM, Prentice, R, Pettinger, M, Thomson, C, Zheng, W, Gao, YT, Rothman, N, Xiang, YB, Cai, H, Wang, R, Yuan, JM, Koh, WP, Butler, LM, Cai, Q, Blot, WJ, Wu, J, Ueland, PM, Midttun, O, Langhammer, A, Hveem, K, Johansson, M, Hultdin, J, Grankvist, K, Arslan, AA, Le Marchand, L, Severi, G, Johansson, M & Brennan, P 2018, 'No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)', Annals of Oncology, vol. 29, no. 6, pp. 1468-1475. https://doi.org/10.1093/annonc/mdy104
Muller, D. C. ; Hodge, A. M. ; Fanidi, A. ; Albanes, D. ; Mai, X. M. ; Shu, X. O. ; Weinstein, S. J. ; Larose, T. L. ; Zhang, X. ; Han, J. ; Stampfer, M. J. ; Smith-Warner, S. A. ; Ma, J. ; Gaziano, J. M. ; Sesso, H. D. ; Stevens, V. L. ; McCullough, M. L. ; Layne, T. M. ; Prentice, R. ; Pettinger, M. ; Thomson, Cynthia ; Zheng, W. ; Gao, Y. T. ; Rothman, N. ; Xiang, Y. B. ; Cai, H. ; Wang, R. ; Yuan, J. M. ; Koh, W. P. ; Butler, L. M. ; Cai, Q. ; Blot, W. J. ; Wu, J. ; Ueland, P. M. ; Midttun, O. ; Langhammer, A. ; Hveem, K. ; Johansson, M. ; Hultdin, J. ; Grankvist, K. ; Arslan, A. A. ; Le Marchand, L. ; Severi, G. ; Johansson, M. ; Brennan, Paul. / No association between circulating concentrations of vitamin D and risk of lung cancer : An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). In: Annals of Oncology. 2018 ; Vol. 29, No. 6. pp. 1468-1475.
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title = "No association between circulating concentrations of vitamin D and risk of lung cancer: An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)",
abstract = "Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95{\%} confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95{\%} CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.",
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T1 - No association between circulating concentrations of vitamin D and risk of lung cancer

T2 - An analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3)

AU - Muller, D. C.

AU - Hodge, A. M.

AU - Fanidi, A.

AU - Albanes, D.

AU - Mai, X. M.

AU - Shu, X. O.

AU - Weinstein, S. J.

AU - Larose, T. L.

AU - Zhang, X.

AU - Han, J.

AU - Stampfer, M. J.

AU - Smith-Warner, S. A.

AU - Ma, J.

AU - Gaziano, J. M.

AU - Sesso, H. D.

AU - Stevens, V. L.

AU - McCullough, M. L.

AU - Layne, T. M.

AU - Prentice, R.

AU - Pettinger, M.

AU - Thomson, Cynthia

AU - Zheng, W.

AU - Gao, Y. T.

AU - Rothman, N.

AU - Xiang, Y. B.

AU - Cai, H.

AU - Wang, R.

AU - Yuan, J. M.

AU - Koh, W. P.

AU - Butler, L. M.

AU - Cai, Q.

AU - Blot, W. J.

AU - Wu, J.

AU - Ueland, P. M.

AU - Midttun, O.

AU - Langhammer, A.

AU - Hveem, K.

AU - Johansson, M.

AU - Hultdin, J.

AU - Grankvist, K.

AU - Arslan, A. A.

AU - Le Marchand, L.

AU - Severi, G.

AU - Johansson, M.

AU - Brennan, Paul

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.

AB - Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.

KW - Case-control

KW - Consortium

KW - Lung cancer

KW - Prospective

KW - Serum 25-hydroxyvitamin D

KW - Vitamin D

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U2 - 10.1093/annonc/mdy104

DO - 10.1093/annonc/mdy104

M3 - Article

C2 - 29617726

AN - SCOPUS:85050815132

VL - 29

SP - 1468

EP - 1475

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

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