No effect of selenium supplementation on serum glucose levels in men with prostate cancer

Amit M. Algotar, Mimi Suzanne Stratton, Steven P. Stratton, Chiu Hsieh Hsu, Frederick R. Ahmann

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background: Literature indicates a relationship between selenium supplementation and risk of diabetes. However, because these data are inconclusive, we investigated the effect of selenium supplementation on serum glucose levels in men with prostate cancer enrolled in a clinical trial testing of the effect of selenium on prostate cancer progression. Methods: Subjects were randomized to receive placebo (n = 46), selenium 200 μg/day (n = 47), and selenium 800 μg/day (n = 47). Serum glucose levels were obtained every 6 months for up to 5 years. Longitudinal analysis was carried out to assess whether rate of change of serum glucose levels was significantly different in the selenium-supplemented groups as compared with placebo. Sensitivity analyses were performed to assess the robustness of findings. Results: Changes in serum glucose levels during the course of the trial were not statistically significantly different as compared with placebo for the selenium 200 μg/day (P = .56) or selenium 800 μg/day (P = .91) treatment groups. Conclusion: These results do not support a relationship between selenium supplementation and changes in serum glucose levels. Recommendations about selenium supplementation and risk of diabetes will require more definitive studies.

Original languageEnglish (US)
Pages (from-to)765-768
Number of pages4
JournalAmerican Journal of Medicine
Volume123
Issue number8
DOIs
StatePublished - Aug 2010

Keywords

  • Prostate cancer
  • Selenium supplementation
  • Serum glucose

ASJC Scopus subject areas

  • Medicine(all)

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