Abstract
Purpose: Current screening for obstructive sleep apnea (OSA) emphasizes self-reported snoring and other breathing symptoms. Nocturia, a symptom with a precise pathophysiological link to sleep apnea, has not been assessed as a screening tool for this common disorder of sleep respiration. In a large sample of adults presenting to area sleep centers, we aimed to determine the predictive power of nocturia for OSA and compare findings with other markers of OSA commonly used to screen for this disease. Methods: This was a retrospective chart review. A consecutive sample of 1,007 adult patients seeking treatment at two sleep centers in New Mexico completed detailed medical and sleep history questionnaires and completed diagnostic polysomnography testing. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nocturia, snoring, high body mass index, sex, and age for OSA were determined. Hierarchical linear regression determined unique variance contribution to the apnea-hypopnea index, the objective measure of sleep apnea severity. Results: The results are as follows: sensitivities - snoring, 82.6% and nocturia, 84.8%; specificities - snoring, 43.0% and nocturia, 22.4%; PPVs - snoring, 84.7% and nocturia, 80.6%; and NPVs - snoring, 39.6% and nocturia, 27.9%. With hierarchical linear regression, patient-reported nocturia frequency predicted apnea-hypopnea index (OSA severity) above and beyond body mass index, sex, age, and self-reported snoring (P<0.0001). Conclusions: Nocturia appears comparable to snoring as a screening tool for OSA in patients presenting to a sleep medical center. Research in urology and primary care clinics is needed to definitively clarify the use of nocturia as a screening instrument for obstructive sleep apnea.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 337-343 |
| Number of pages | 7 |
| Journal | Sleep and Breathing |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 2010 |
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Keywords
- Clinical screening
- Nocturia
- Obstructive sleep apnea
- Snore
ASJC Scopus subject areas
- Otorhinolaryngology
- Clinical Neurology
Cite this
Nocturia and snoring : Predictive symptoms for obstructive sleep apnea. / Romero, Edward; Krakow, Barry; Haynes, Patricia L; Ulibarri, Victor.
In: Sleep and Breathing, Vol. 14, No. 4, 12.2010, p. 337-343.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nocturia and snoring
T2 - Predictive symptoms for obstructive sleep apnea
AU - Romero, Edward
AU - Krakow, Barry
AU - Haynes, Patricia L
AU - Ulibarri, Victor
PY - 2010/12
Y1 - 2010/12
N2 - Purpose: Current screening for obstructive sleep apnea (OSA) emphasizes self-reported snoring and other breathing symptoms. Nocturia, a symptom with a precise pathophysiological link to sleep apnea, has not been assessed as a screening tool for this common disorder of sleep respiration. In a large sample of adults presenting to area sleep centers, we aimed to determine the predictive power of nocturia for OSA and compare findings with other markers of OSA commonly used to screen for this disease. Methods: This was a retrospective chart review. A consecutive sample of 1,007 adult patients seeking treatment at two sleep centers in New Mexico completed detailed medical and sleep history questionnaires and completed diagnostic polysomnography testing. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nocturia, snoring, high body mass index, sex, and age for OSA were determined. Hierarchical linear regression determined unique variance contribution to the apnea-hypopnea index, the objective measure of sleep apnea severity. Results: The results are as follows: sensitivities - snoring, 82.6% and nocturia, 84.8%; specificities - snoring, 43.0% and nocturia, 22.4%; PPVs - snoring, 84.7% and nocturia, 80.6%; and NPVs - snoring, 39.6% and nocturia, 27.9%. With hierarchical linear regression, patient-reported nocturia frequency predicted apnea-hypopnea index (OSA severity) above and beyond body mass index, sex, age, and self-reported snoring (P<0.0001). Conclusions: Nocturia appears comparable to snoring as a screening tool for OSA in patients presenting to a sleep medical center. Research in urology and primary care clinics is needed to definitively clarify the use of nocturia as a screening instrument for obstructive sleep apnea.
AB - Purpose: Current screening for obstructive sleep apnea (OSA) emphasizes self-reported snoring and other breathing symptoms. Nocturia, a symptom with a precise pathophysiological link to sleep apnea, has not been assessed as a screening tool for this common disorder of sleep respiration. In a large sample of adults presenting to area sleep centers, we aimed to determine the predictive power of nocturia for OSA and compare findings with other markers of OSA commonly used to screen for this disease. Methods: This was a retrospective chart review. A consecutive sample of 1,007 adult patients seeking treatment at two sleep centers in New Mexico completed detailed medical and sleep history questionnaires and completed diagnostic polysomnography testing. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of nocturia, snoring, high body mass index, sex, and age for OSA were determined. Hierarchical linear regression determined unique variance contribution to the apnea-hypopnea index, the objective measure of sleep apnea severity. Results: The results are as follows: sensitivities - snoring, 82.6% and nocturia, 84.8%; specificities - snoring, 43.0% and nocturia, 22.4%; PPVs - snoring, 84.7% and nocturia, 80.6%; and NPVs - snoring, 39.6% and nocturia, 27.9%. With hierarchical linear regression, patient-reported nocturia frequency predicted apnea-hypopnea index (OSA severity) above and beyond body mass index, sex, age, and self-reported snoring (P<0.0001). Conclusions: Nocturia appears comparable to snoring as a screening tool for OSA in patients presenting to a sleep medical center. Research in urology and primary care clinics is needed to definitively clarify the use of nocturia as a screening instrument for obstructive sleep apnea.
KW - Clinical screening
KW - Nocturia
KW - Obstructive sleep apnea
KW - Snore
UR - http://www.scopus.com/inward/record.url?scp=79956156892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79956156892&partnerID=8YFLogxK
U2 - 10.1007/s11325-009-0310-2
DO - 10.1007/s11325-009-0310-2
M3 - Article
C2 - 19865841
AN - SCOPUS:79956156892
VL - 14
SP - 337
EP - 343
JO - Sleep and Breathing
JF - Sleep and Breathing
SN - 1520-9512
IS - 4
ER -