Non-human primate models of T-cell reconstitution

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Non-human primates (NHP) have become an indispensable model in studying the common and dangerous human chronic infections, including HIV/SIV, Hepatitis C virus, and tuberculosis. More recently, we and others have used aged NHP to model human immune aging. Chronic infections and aging are both characterized by a significant depletion of defined lymphocyte subsets and the compensatory attempts to regenerate the immune system. As the efficacious antiviral drugs and novel methods to improve and boost the immune system emerge, therapeutic immune regeneration has become a realistic goal in both the physiologic and pathologic settings. This article will summarize our current knowledge on this topic and will discuss future research directions as well as the potential and power of translational studies in non-human primate models of infection, aging and bone marrow transplantation.

Original languageEnglish (US)
Pages (from-to)310-317
Number of pages8
JournalSeminars in Immunology
Volume19
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Primates
T-Lymphocytes
Immune System
Lymphocyte Subsets
Infection
Bone Marrow Transplantation
Hepacivirus
HIV Infections
Antiviral Agents
Regeneration
Tuberculosis
Therapeutics
Direction compound

Keywords

  • Aging
  • Cytokines
  • Monkey
  • Reconstitution
  • T-cells
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Non-human primate models of T-cell reconstitution. / Nikolich-Zugich, Janko.

In: Seminars in Immunology, Vol. 19, No. 5, 10.2007, p. 310-317.

Research output: Contribution to journalArticle

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