Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)

Joseph A. Tangrea, Paul S. Albert, Elaine Lanza, Karen Woodson, Don Corle, Marsha Hasson, Randall Burt, Bette Caan, Electra Páskett, Frank Iber, J. Walter Kikendall, Peter Lance, Moshe Shike, Joel Weissfeld, Arthur Schatzkin

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Objective: To prospectively examine the association between non-steroidal anti-inflammatory drugs (NSAIDs) use (including dose and dosage schedule) and the recurrence of colorectal adenomas among individuals who were diagnosed with an adenoma at entry into a clinical trial. Methods: For this analysis, participants who completed the full follow-up (n=1905) for the Polyp Prevention Trial (PPT) were evaluated. Information on current use and dose of NSAIDs and other drugs was obtained at baseline and at each subsequent study visit over the duration of the trial. The study endpoint was the recurrence of colorectal adenomas in the 3 years between the 1-year trial colonoscopy (T1) and the end of the trial colonoscopy (T4). Results: There was a significant reduction in overall adenoma recurrence among NSAIDs users (odds ratio [OR]=0.77; 95% confidence interval [CI]: 0.63-0.95), with the greatest effect seen in advanced polyps (OR=0.51; CI: 0.33 0.79). Among aspirin users, we observed a significant dose response for overall adenoma recurrence, with a 40% reduction in the OR association (OR=0.56; 95% CI: 0.31-0.99) among those taking more than 325 mg per day. Conclusion: This prospective study provides further evidence that NSAIDs may play an important role in the chemoprevention of recurrent colorectal adenomas, even those with advanced features.

Original languageEnglish (US)
Pages (from-to)403-411
Number of pages9
JournalCancer Causes and Control
Volume14
Issue number5
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Keywords

  • Adenomas
  • Non-steroidal anti-inflammatory drugs
  • Prospective
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tangrea, J. A., Albert, P. S., Lanza, E., Woodson, K., Corle, D., Hasson, M., Burt, R., Caan, B., Páskett, E., Iber, F., Kikendall, J. W., Lance, P., Shike, M., Weissfeld, J., & Schatzkin, A. (2003). Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States). Cancer Causes and Control, 14(5), 403-411. https://doi.org/10.1023/A:1024990617158