Nonalcoholic fatty liver disease in children living in the obeseogenic society

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Background: The problem of obesity in children has grown considerably in recent years in the United States as well as the rest of the world. This has resulted in a marked increase in the prevalence of nonalcoholic liver disease in the pediatric age group. Nonalcoholic fatty liver disease (NAFLD) is currently the most common hepatic disorder seen in pediatric hepatology practice. Data sources: We have reviewed the most recent literature regarding the prevalence, pathogenesis as well as the most recent advances in the diagnostic and therapeutic modalities of NAFLD in children. Results: NAFLD affects a substantial portion of the population including children. Conclusions: The rising incidence of NAFLD, nonalcoholic steatohepatitis (NASH) and cirrhosis emphasizes the need for effective treatment options. The lack of complete understanding of the pathogenesis of NAFLD still limits our ability to develop novel therapeutic modalities that can target the metabolic derangements implicated in the development of the disorder.

Original languageEnglish (US)
Pages (from-to)245-254
Number of pages10
JournalWorld Journal of Pediatrics
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2009

Keywords

  • Fatty liver
  • Nonalcoholic fatty liver disease
  • Obesity
  • Pediatric liver disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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