Noncirrhotic portal fibrosis after Wilms' tumor therapy

John A. Barnard, Gary S. Marshall, Wallace W. Neblett, George Gray, Fayez K. Ghishan

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy.

Original languageEnglish (US)
Pages (from-to)1054-1056
Number of pages3
JournalGastroenterology
Volume90
Issue number4
DOIs
StatePublished - Apr 1986
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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