Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides

Min Zhou, Indraneel Ghosh

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

(Chemical Equation Presented) The synthesis and characterization of a new leucine-zipper dendrimer (LZD) is reported that displays four copies of the peptide corresponding to the coiled-coiled dimerization domain of Fos. Circular dichroism spectroscopy, fluorescence titration, and sedimentation equilibrium experiments demonstrate that Fos-LZD can noncovalently assemble four copies of the peptide corresponding to the coiled-coil domain of Jun. This work provides the basis for the future construction of noncovalently assembled multivalent protein assemblies displaying any protein of interest.

Original languageEnglish (US)
Pages (from-to)3561-3564
Number of pages4
JournalOrganic Letters
Volume6
Issue number20
DOIs
StatePublished - Sep 30 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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