Noninteraction of Digitoxin and Quinidine

Kenneth R. Melvin, Robert E. Kates, Douglas E. Rollins, Moshe Garty, Paul E. Fenster, Frank I. Marcus, Kenneth Conrad, Penelope E. Graves, W. David Hager, J. Robert Powell, Hermann R. Ochs, David J. Greenblatt

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To the Editor: The study design employed by Ochs et al. in their article in the September 18 issue partly explains their negative findings. Previous studies by many groups1 2 3 have shown a definitive interaction between digoxin and quinidine, and the method used in most of these studies has been to increase doses until patients have steady-state digoxin levels, and then to introduce quinidine and study the effect. A similar study designed by Storstein et al.4 measured the changing clearance and serum elimination half-time in fully digitalized patients who were given quinidine. Peters et al.5 also studied fully digitalized patients, who.

Original languageEnglish (US)
Pages (from-to)118-119
Number of pages2
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jan 8 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Melvin, K. R., Kates, R. E., Rollins, D. E., Garty, M., Fenster, P. E., Marcus, F. I., Conrad, K., Graves, P. E., Hager, W. D., Powell, J. R., Ochs, H. R., & Greenblatt, D. J. (1981). Noninteraction of Digitoxin and Quinidine. New England Journal of Medicine, 304(2), 118-119.