Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy

Mark "Marty" Pagel, James P. Basilion

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

INTRODUCTION Magnetic resonance imaging (MRI) has developed from an intriguing research project initially conceived in 1973 to an essential diagnostic method in the armamentarium of clinical radiologists. An estimated 26.6 million MRI procedures were performed in 2006 in the United States that generated approximately $20 billion in service revenue. The demand for clinical MRI diagnoses is expected to increase by 30% by 2020. This projected growth is due in part to the rising prevalence of age-related pathologies of soft tissues that can be conveniently monitored with MRI, such as the anatomy of pathologies in the cardiopulmonary system (e.g., regions of myocardial infarcts), neurological system (e.g., regions of cerebral infarcts, morphological changes during multiple sclerosis), and musculoskeletal system (e.g., tears in ligaments, tendons, and cartilage). MRI offers advantages relative to optical imaging methods limited to making diagnoses only near tissue surfaces, and relative to PET, SPECT, CT, and X-ray imaging methods that use potentially harmful ionizing radiation. Unlike these other imaging modalities, MRI also provides excellent spatial resolution at or smaller than 1 mm3 for clinical diagnostics and approaching 0.1 mm3 for small-animal research studies. MRI can also assess physiological function, such as the function of the cardiopulmonary system (e.g., MR angiography of vasculature), neurological system (e.g., fMRI of brain activity), renal system (e.g., perfusion imaging of kidney function), musculoskeletal system (e.g., MR elastography of connective tissues), and cancer lesions (e.g., dynamic contrast enhancement MRI of angiogenic tumors).

Original languageEnglish (US)
Title of host publicationMolecular Imaging with Reporter Genes
PublisherCambridge University Press
Pages88-110
Number of pages23
ISBN (Electronic)9780511730405
ISBN (Print)9780521882330
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Magnetic resonance spectroscopy
Magnetic resonance
Gene expression
Magnetic resonance imaging
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Gene Expression
Imaging techniques
Musculoskeletal system
Musculoskeletal System
Pathology
Tissue
Angiography
Kidney
Elasticity Imaging Techniques
Ligaments
Tendons
Ionizing radiation
Cartilage
Perfusion Imaging

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Pagel, M. M., & Basilion, J. P. (2010). Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy. In Molecular Imaging with Reporter Genes (pp. 88-110). Cambridge University Press. https://doi.org/10.1017/CBO9780511730405.005

Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy. / Pagel, Mark "Marty"; Basilion, James P.

Molecular Imaging with Reporter Genes. Cambridge University Press, 2010. p. 88-110.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pagel, MM & Basilion, JP 2010, Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy. in Molecular Imaging with Reporter Genes. Cambridge University Press, pp. 88-110. https://doi.org/10.1017/CBO9780511730405.005
Pagel, Mark "Marty" ; Basilion, James P. / Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy. Molecular Imaging with Reporter Genes. Cambridge University Press, 2010. pp. 88-110
@inbook{a1aae23261a84ef68f3894588053ba1d,
title = "Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy",
abstract = "INTRODUCTION Magnetic resonance imaging (MRI) has developed from an intriguing research project initially conceived in 1973 to an essential diagnostic method in the armamentarium of clinical radiologists. An estimated 26.6 million MRI procedures were performed in 2006 in the United States that generated approximately $20 billion in service revenue. The demand for clinical MRI diagnoses is expected to increase by 30{\%} by 2020. This projected growth is due in part to the rising prevalence of age-related pathologies of soft tissues that can be conveniently monitored with MRI, such as the anatomy of pathologies in the cardiopulmonary system (e.g., regions of myocardial infarcts), neurological system (e.g., regions of cerebral infarcts, morphological changes during multiple sclerosis), and musculoskeletal system (e.g., tears in ligaments, tendons, and cartilage). MRI offers advantages relative to optical imaging methods limited to making diagnoses only near tissue surfaces, and relative to PET, SPECT, CT, and X-ray imaging methods that use potentially harmful ionizing radiation. Unlike these other imaging modalities, MRI also provides excellent spatial resolution at or smaller than 1 mm3 for clinical diagnostics and approaching 0.1 mm3 for small-animal research studies. MRI can also assess physiological function, such as the function of the cardiopulmonary system (e.g., MR angiography of vasculature), neurological system (e.g., fMRI of brain activity), renal system (e.g., perfusion imaging of kidney function), musculoskeletal system (e.g., MR elastography of connective tissues), and cancer lesions (e.g., dynamic contrast enhancement MRI of angiogenic tumors).",
author = "Pagel, {Mark {"}Marty{"}} and Basilion, {James P.}",
year = "2010",
month = "1",
day = "1",
doi = "10.1017/CBO9780511730405.005",
language = "English (US)",
isbn = "9780521882330",
pages = "88--110",
booktitle = "Molecular Imaging with Reporter Genes",
publisher = "Cambridge University Press",
address = "United Kingdom",

}

TY - CHAP

T1 - Noninvasive imaging of gene expression with magnetic resonance imaging and magnetic resonance spectroscopy

AU - Pagel, Mark "Marty"

AU - Basilion, James P.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - INTRODUCTION Magnetic resonance imaging (MRI) has developed from an intriguing research project initially conceived in 1973 to an essential diagnostic method in the armamentarium of clinical radiologists. An estimated 26.6 million MRI procedures were performed in 2006 in the United States that generated approximately $20 billion in service revenue. The demand for clinical MRI diagnoses is expected to increase by 30% by 2020. This projected growth is due in part to the rising prevalence of age-related pathologies of soft tissues that can be conveniently monitored with MRI, such as the anatomy of pathologies in the cardiopulmonary system (e.g., regions of myocardial infarcts), neurological system (e.g., regions of cerebral infarcts, morphological changes during multiple sclerosis), and musculoskeletal system (e.g., tears in ligaments, tendons, and cartilage). MRI offers advantages relative to optical imaging methods limited to making diagnoses only near tissue surfaces, and relative to PET, SPECT, CT, and X-ray imaging methods that use potentially harmful ionizing radiation. Unlike these other imaging modalities, MRI also provides excellent spatial resolution at or smaller than 1 mm3 for clinical diagnostics and approaching 0.1 mm3 for small-animal research studies. MRI can also assess physiological function, such as the function of the cardiopulmonary system (e.g., MR angiography of vasculature), neurological system (e.g., fMRI of brain activity), renal system (e.g., perfusion imaging of kidney function), musculoskeletal system (e.g., MR elastography of connective tissues), and cancer lesions (e.g., dynamic contrast enhancement MRI of angiogenic tumors).

AB - INTRODUCTION Magnetic resonance imaging (MRI) has developed from an intriguing research project initially conceived in 1973 to an essential diagnostic method in the armamentarium of clinical radiologists. An estimated 26.6 million MRI procedures were performed in 2006 in the United States that generated approximately $20 billion in service revenue. The demand for clinical MRI diagnoses is expected to increase by 30% by 2020. This projected growth is due in part to the rising prevalence of age-related pathologies of soft tissues that can be conveniently monitored with MRI, such as the anatomy of pathologies in the cardiopulmonary system (e.g., regions of myocardial infarcts), neurological system (e.g., regions of cerebral infarcts, morphological changes during multiple sclerosis), and musculoskeletal system (e.g., tears in ligaments, tendons, and cartilage). MRI offers advantages relative to optical imaging methods limited to making diagnoses only near tissue surfaces, and relative to PET, SPECT, CT, and X-ray imaging methods that use potentially harmful ionizing radiation. Unlike these other imaging modalities, MRI also provides excellent spatial resolution at or smaller than 1 mm3 for clinical diagnostics and approaching 0.1 mm3 for small-animal research studies. MRI can also assess physiological function, such as the function of the cardiopulmonary system (e.g., MR angiography of vasculature), neurological system (e.g., fMRI of brain activity), renal system (e.g., perfusion imaging of kidney function), musculoskeletal system (e.g., MR elastography of connective tissues), and cancer lesions (e.g., dynamic contrast enhancement MRI of angiogenic tumors).

UR - http://www.scopus.com/inward/record.url?scp=84932163837&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84932163837&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511730405.005

DO - 10.1017/CBO9780511730405.005

M3 - Chapter

AN - SCOPUS:84932163837

SN - 9780521882330

SP - 88

EP - 110

BT - Molecular Imaging with Reporter Genes

PB - Cambridge University Press

ER -