Nonlinear interactions between excitatory and inhibitory

Botir T. Sagdullaev, Erika D. Eggers, Robert Purgert, Peter D. Lukasiewicz

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The visual system is highly sensitive to dynamic features in the visual scene. However, it is not known how or where this enhanced sensitivity first occurs. We investigated this phenomenon by studying interactions between excitatory and inhibitory synapses in the second synaptic layer of the mouse retina. We found that these interactions showed activity-dependent changes that enhanced signaling of dynamic stimuli. Excitatory signaling from cone bipolar cells to ganglion cells exhibited strong synaptic depression, attributable to reduced glutamate release from bipolar cells. This depression was relieved by amacrine cell inhibitory feedback that activated presynaptic GABAC receptors. We found that the balance between excitation and feedback inhibition depended on stimulus frequency; at short interstimulus intervals, excitation was enhanced, attributable to reduced inhibitory feedback. This dynamic interplay may enrich visual processing by enhancing retinal responses to closely spaced temporal events, representing rapid changes in the visual environment.

Original languageEnglish (US)
Pages (from-to)15102-15112
Number of pages11
JournalJournal of Neuroscience
Volume31
Issue number42
DOIs
StatePublished - Oct 19 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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