Normal fMRI brain activation patterns in children performing a verb generation task

Scott K. Holland, Elena M Plante, Anna Weber Byars, Richard H. Strawsburg, Vince J. Schmithorst, William S. Ball

Research output: Contribution to journalArticle

291 Citations (Scopus)

Abstract

Although much is known concerning brain-language relations in adults, little is known about how these functions might be represented during the developmental period. We report results from 17 normal children, ages 7-18 years, who have successfully completed a word fluency paradigm during functional magnetic resonance imaging at 3 Tesla. Regions of activation replicate those reported for adult subjects. However, a statistically significant association between hemispheric lateralization of activation and age was found in the children. Specifically, although most subjects at all ages showed left hemisphere dominance for this task, the degree of lateralization increased with age. This study demonstrates that fMRI can reveal developmental shifts in the pattern of brain activation associated with semantic language function.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
JournalNeuroImage
Volume14
Issue number4
DOIs
StatePublished - 2001

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Language
Magnetic Resonance Imaging
Brain
Semantics

Keywords

  • Brain
  • Child
  • Development
  • fMRI
  • Language
  • MRI
  • Pediatric
  • Speech

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Holland, S. K., Plante, E. M., Weber Byars, A., Strawsburg, R. H., Schmithorst, V. J., & Ball, W. S. (2001). Normal fMRI brain activation patterns in children performing a verb generation task. NeuroImage, 14(4), 837-843. https://doi.org/10.1006/nimg.2001.0875

Normal fMRI brain activation patterns in children performing a verb generation task. / Holland, Scott K.; Plante, Elena M; Weber Byars, Anna; Strawsburg, Richard H.; Schmithorst, Vince J.; Ball, William S.

In: NeuroImage, Vol. 14, No. 4, 2001, p. 837-843.

Research output: Contribution to journalArticle

Holland, SK, Plante, EM, Weber Byars, A, Strawsburg, RH, Schmithorst, VJ & Ball, WS 2001, 'Normal fMRI brain activation patterns in children performing a verb generation task', NeuroImage, vol. 14, no. 4, pp. 837-843. https://doi.org/10.1006/nimg.2001.0875
Holland, Scott K. ; Plante, Elena M ; Weber Byars, Anna ; Strawsburg, Richard H. ; Schmithorst, Vince J. ; Ball, William S. / Normal fMRI brain activation patterns in children performing a verb generation task. In: NeuroImage. 2001 ; Vol. 14, No. 4. pp. 837-843.
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