Normalization of nutritional status by various levels of vitamin E supplementation during murine AIDS

Yuejian Wang, Bailin Liang, Ronald R. Watson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS which is functionally similar to human AIDS. Dietary supplementation, with a 15-, 150- and 450-fold increase of vitamin E in a liquid diet (National Council Research), significantly restored serum and haptic vitamin A and E which had been reduced by retrovirus infection. They also significantly restored hepatic copper, which had been reduced by retrovirus infection, whereas only 150- and 450-fold vitamin E improved hepatic zinc level. Vitamin E supplementation at all levels had no effects on hepatic zinc and copper levels in normal mice, whereas they significantly increased serum and hepatic vitamin A and E concentrations. Vitamin E supplementation at all levels significantly increased intestinal vitamin A and E levels during murine AIDS, whereas only intestinal vitamin E levels was altered by various levels of vitamin E supplementation. Interestingly, vitamin E supplementation had no effect on intestinal copper level, whereas they significantly increased intestinal zinc level in the normal mice and only 450-fold vitamin E supplementation significantly elevated intestinal level of zinc. These data indicate that dietary vitamin E supplementation at extremely high levels was not toxic, can improve undernutrition initiated by retrovirus infection during progression to murine AIDS, which should favorably affect immune response.

Original languageEnglish (US)
Pages (from-to)1375-1386
Number of pages12
JournalNutrition Research
Volume14
Issue number9
DOIs
StatePublished - Sep 1994

Keywords

  • Nutrition and Murine AIDS
  • Vitamin E

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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