Normalization of periictal bihemispheric cerebral perfusion in temporal lobe epilepsy

Gabriel Gonzalez-Portillo, Sergio Rivero, Geoffrey L Ahern, David M Labiner, Martin E Weinand

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Under normal circumstances, cerebral blood flow (CBF), between the two hemispheres is coupled in a direct (i.e. positive slope), linear fashion. However, in temporal lobe epilepsy, the relationship between the two temporal cortices, during the interictal and postictal periods, is the inverse of normal (i.e. correlation is with negative slope and linear). Long-term combined temporal lobe thermal diffusion flowmetry (TDF) subdural regional cerebral blood flow and electroencephalographic (EEG) recording was performed to test the hypothesis that, during the 10 min periictal period (i.e. 5 min before and 5 min following clinical seizure onset), the cerebral perfusion relationship between epileptic and nonepileptic cortex returns to normal (i.e. becomes direct, with positive slope, and linear). A consecutive series of 13 patients with complex partial epilepsy was studied. During continuous monitoring of clinical phenomenology in time sequence with subdural CBF/EEG, the 10 min periictal period was characterized by a direct, linear correlation between epileptic and nonepileptic temporal cortical blood flow (r=0.302, d.f.=85, t=2.921, P<0.01). The fact that this pertubation in the CBF relationship between the bilateral temporal cortices begins prior to and continues for 5 min following clinical and subdural EEG seizure onset raises the interesting possibility that normalization of periictal bilateral cerebral perfusion may be associated with temporal lobe epileptogenesis.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalPathophysiology
Volume11
Issue number1
DOIs
StatePublished - Jul 2004

Fingerprint

Cerebrovascular Circulation
Temporal Lobe Epilepsy
Temporal Lobe
Perfusion
Seizures
Thermal Diffusion
Complex Partial Epilepsy
Rheology
Regional Blood Flow

Keywords

  • Cerebral blood flow
  • Electroencephalography
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Normalization of periictal bihemispheric cerebral perfusion in temporal lobe epilepsy. / Gonzalez-Portillo, Gabriel; Rivero, Sergio; Ahern, Geoffrey L; Labiner, David M; Weinand, Martin E.

In: Pathophysiology, Vol. 11, No. 1, 07.2004, p. 31-34.

Research output: Contribution to journalArticle

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