Normothermic renal artery perfusion

A comparison of perfusates

John D Hughes, Changyi Chen, Samer G. Mattar, Ayten Someren, Beverly Noe, Carolyn R. Suwyn, Alan B. Lumsden

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypothermia and preservative perfusates have been used to decrease ischemic renal injury. This study was performed to identify the preservative function of perfusates independent of the effects of hypothermia. Rats underwent 45 minutes of renal ischemia. Rectal and renal parenchyma temperatures were monitored and maintained within 1° C of normal. Perfusates were University of Wisconsin solution (UW), Euro-Collins solution, normal saline solution, and Ringer's lactate solution. A nonperfused ischemic control and a nonischemic control group were also evaluated. Parameters evaluated included serum creatinine and blood urea nitrogen levels, renal ischemic injury grade, renal weight, and gross appearance of the injured kidney. Rats treated with UW solution were found to have a significantly lower creatinine, blood urea nitrogen, and injury grade than the other three perfused groups. The external gross appearance of the UW-treated kidneys was normal, whereas that of the other groups demonstrated moderate to severe injury. Although the mean right/left renal weight difference of the UW- treated group was lower than that of the other three groups, this was not statistically significant. Under normothermic conditions in rats, UW solution affords significant renal protection from ischemia, Euro-Collins, normal saline, and Ringer's lactate solutions display no significant protective effect.

Original languageEnglish (US)
Pages (from-to)123-130
Number of pages8
JournalAnnals of Vascular Surgery
Volume10
Issue number2
DOIs
StatePublished - Mar 1996
Externally publishedYes

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Renal Artery
Perfusion
Kidney
Blood Urea Nitrogen
Wounds and Injuries
Hypothermia
Creatinine
Ischemia
Weights and Measures
Sodium Chloride
Control Groups
Temperature
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hughes, J. D., Chen, C., Mattar, S. G., Someren, A., Noe, B., Suwyn, C. R., & Lumsden, A. B. (1996). Normothermic renal artery perfusion: A comparison of perfusates. Annals of Vascular Surgery, 10(2), 123-130. https://doi.org/10.1007/BF02000755

Normothermic renal artery perfusion : A comparison of perfusates. / Hughes, John D; Chen, Changyi; Mattar, Samer G.; Someren, Ayten; Noe, Beverly; Suwyn, Carolyn R.; Lumsden, Alan B.

In: Annals of Vascular Surgery, Vol. 10, No. 2, 03.1996, p. 123-130.

Research output: Contribution to journalArticle

Hughes, JD, Chen, C, Mattar, SG, Someren, A, Noe, B, Suwyn, CR & Lumsden, AB 1996, 'Normothermic renal artery perfusion: A comparison of perfusates', Annals of Vascular Surgery, vol. 10, no. 2, pp. 123-130. https://doi.org/10.1007/BF02000755
Hughes, John D ; Chen, Changyi ; Mattar, Samer G. ; Someren, Ayten ; Noe, Beverly ; Suwyn, Carolyn R. ; Lumsden, Alan B. / Normothermic renal artery perfusion : A comparison of perfusates. In: Annals of Vascular Surgery. 1996 ; Vol. 10, No. 2. pp. 123-130.
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