Novel anti-β-functionalized γ,δ-unsaturated amino acids via a thio-Claisen rearrangement

Zhihua Liu, Hongchang Qu, Xuyuan Gu, Kwang Soo Lee, Bryan Grossman, Vlad K. Kumirov, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A significantly improved thio-Claisen rearrangement method was developed for preparing anti-β-functionalized γ,δ-unsaturated amino acids, which are extremely useful nonproteinogenic amino acids used in chemistry and biology research. The mild reaction condition successfully introduced base labile functional groups into the amino acids with excellent anti/syn selectivities.

Original languageEnglish (US)
Pages (from-to)3518-3520
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number27
DOIs
StatePublished - Jul 7 2010

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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