Novel applications of ethyl glyoxalate with the Ugi MCR

Christopher Hulme, M. P. Cherrier

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.

Original languageEnglish (US)
Pages (from-to)5295-5299
Number of pages5
JournalTetrahedron Letters
Volume40
Issue number29
DOIs
StatePublished - Jul 16 1999
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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