Novel applications of ethyl glyoxalate with the Ugi MCR

Christopher Hulme, M. P. Cherrier

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

This letter describes novel high-yielding solution phase preparations of 1,4-benzodiazepine-2,5-dione, diketopiperazine, ketopiperazine and dihydroquinoxalinone libraries via a UDC (Ugi/de-Boc/cyclization) strategy in combination with ethylglyoxalate. The methodology represents a 'three step, one-pot procedure', employing the Ugi multi-component reaction (MCR), followed by Boc deprotection and cyclization.

Original languageEnglish (US)
Pages (from-to)5295-5299
Number of pages5
JournalTetrahedron Letters
Volume40
Issue number29
DOIs
StatePublished - Jul 16 1999
Externally publishedYes

Fingerprint

Cyclization
Diketopiperazines
Libraries
ethyl glyoxalate
Bz-423

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Novel applications of ethyl glyoxalate with the Ugi MCR. / Hulme, Christopher; Cherrier, M. P.

In: Tetrahedron Letters, Vol. 40, No. 29, 16.07.1999, p. 5295-5299.

Research output: Contribution to journalArticle

Hulme, Christopher ; Cherrier, M. P. / Novel applications of ethyl glyoxalate with the Ugi MCR. In: Tetrahedron Letters. 1999 ; Vol. 40, No. 29. pp. 5295-5299.
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