Novel approaches to using PDE4 inhibitors for antihypertensive therapy

Desuo Wang, Ting Wang

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Phosphodiesterase (PDE)4 inhibitors are effective vasodilators. In addition to the treatment of asthma and other inflammatory diseases, such as chronic obstructive pulmonary disease, wide-spectrum PDE4 inhibitors may also be developed for use in antihypertensive therapy, especially in patients with impaired renal function and elevated pulmonary arterial pressure. Rational approaches to overcoming the intrinsic emetogenic response associated with PDE4 inhibition are discussed, and a dual-action drug development that incorporates L-type Ca2+ channel antagonism and selective PDE4 inhibition is proposed. The potential for research and development of such a dual-action agent should eventually provide healthcare professionals with a new category of therapeutic options with which to attempt to combat hypertension.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Volume6
Issue number3
StatePublished - Mar 1 2005
Externally publishedYes

Keywords

  • Blood pressure
  • Dual-action therapy
  • Hypertension
  • Phosphodiesterase 4 inhibitor
  • Vasodilation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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