Novel extrusion system for the encapsulation of drug releasing bio-medical micro-robots

Eniko T Enikov, Malcolm T. Gibson, Stephane J. Ritty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper examines the design and testing of a novel extrusion system for the biocompatible coating of drug delivering micro-robots. The encapsulation system creates monodisperse droplets of sodium alginate containing the micro-robots within a coaxial laminar flow of a continuous oil phase. The extrusion process allows the experimenter to control the size of the drug carrying droplets which have been subsequently tested as vehicles to deliver a model drug (Horseradish peroxidase). Comparison with other coating techniques such as dip-coating shows significant increase in the drug storing capacity. A demonstration of the use of ultrasound as a possible trigger of the drug release has also been presented. The significant increase in the observed drug release rate shows enhancement over previously tested passive diffusion and magnetic modulation methods. Together, these two aspects of micro-robotic drug delivery concept introduce a new approach to drug-delivering microrobots with large drug-storage capacity, ability to propel the robots using magnetic forces, and trigger the drugrelease by remote application of ultrasonic stimulation.

Original languageEnglish (US)
Title of host publication2009 ICME International Conference on Complex Medical Engineering, CME 2009
DOIs
Publication statusPublished - 2009
Event2009 ICME International Conference on Complex Medical Engineering, CME 2009 - Tempe, AZ, United States
Duration: Apr 9 2009Apr 11 2009

Other

Other2009 ICME International Conference on Complex Medical Engineering, CME 2009
CountryUnited States
CityTempe, AZ
Period4/9/094/11/09

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ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

Cite this

Enikov, E. T., Gibson, M. T., & Ritty, S. J. (2009). Novel extrusion system for the encapsulation of drug releasing bio-medical micro-robots. In 2009 ICME International Conference on Complex Medical Engineering, CME 2009 [4906603] https://doi.org/10.1109/ICCME.2009.4906603