Novel focused OCT-LIF endoscope

R. Andrew Wall, Garret T. Bonnema, Jennifer K Barton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalBiomedical Optics Express
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2011

Fingerprint

endoscopes
Endoscopes
Optical Coherence Tomography
laser induced fluorescence
Lasers
tomography
Fluorescence
wavelengths
Adenoma
Lenses
Endoscopy
balls
lenses
Sensitivity and Specificity
sensitivity
high resolution
diffraction

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Novel focused OCT-LIF endoscope. / Wall, R. Andrew; Bonnema, Garret T.; Barton, Jennifer K.

In: Biomedical Optics Express, Vol. 2, No. 3, 01.03.2011, p. 421-430.

Research output: Contribution to journalArticle

Wall, R. Andrew ; Bonnema, Garret T. ; Barton, Jennifer K. / Novel focused OCT-LIF endoscope. In: Biomedical Optics Express. 2011 ; Vol. 2, No. 3. pp. 421-430.
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