Novel focused OCT-LIF endoscope

R. Andrew Wall, Garret T. Bonnema, Jennifer K. Barton

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.

Original languageEnglish (US)
Pages (from-to)421-430
Number of pages10
JournalBiomedical Optics Express
Volume2
Issue number3
DOIs
StatePublished - Mar 1 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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