Novel segment polarity gene interactions during embryonic head development in Drosophila

Amelia Gallitano-Mendel, Robert Finkelstein

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

In the trunk of the Drosophila embryo, the segment polarity genes are initially activated by the pair-rule genes, and later maintain each other's expression through a complex network of cross-regulatory interactions. These interactions, which are critical to cell fate specification, are similar in each of the trunk segments. To determine whether segment polarity gene expression is established differently outside the trunk, we studied the regulation of the genes hedgehog (hh), wingless (wg), and engrailed (en) in each of the segments of the developing head. We show that the cross- regulatory relationships among these genes, as well as their initial mode of activation, in the anterior head are significantly different from those in the trunk. In addition, each head segment exhibits a unique network of segment polarity gene interactions. We propose that these segment-specific interactions evolved to specify the high degree of structural diversity required for head morphogenesis.

Original languageEnglish (US)
Pages (from-to)599-613
Number of pages15
JournalDevelopmental biology
Volume192
Issue number2
DOIs
StatePublished - Dec 15 1997
Externally publishedYes

Keywords

  • Drosophila
  • Engrailed
  • Head development
  • Hedgehog
  • Patched
  • Wingless

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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