Novel Use of Doxycycline in Continuous-Instillation Negative Pressure Wound Therapy as “Wound Chemotherapy”

Christy L. Scimeca, Manish Bharara, Timothy K. Fisher, Nicholas Giovinco, David G. Armstrong

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Negative-pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. The authors present a description of real-time streaming therapy of a variety of wound chemotherapeutic agents through NPWT. Doxycycline, which acts as a competitive inhibitor of matrix metalloproteinases and tumor necrosis factor alpha and further decreases inflammation through the reduction of nitrous oxide production, may prove helpful when delivered in this manner. To the authors’ knowledge, this is the first report in the literature describing this method of delivery of doxycycline.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalFoot & Ankle Specialist
Volume3
Issue number4
DOIs
StatePublished - Aug 2010

Keywords

  • amputation and limb salvage
  • inflammation
  • nonhealing ulcer

ASJC Scopus subject areas

  • Surgery
  • Podiatry
  • Orthopedics and Sports Medicine

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