Novel use of insulin in continuous-instillation negative pressure wound therapy as "wound chemotherapy"

Christy L. Scimeca, Manish Bharara, Timothy K. Fisher, Heather Kimbriel, Joseph L. Mills, David G. Armstrong

Research output: Contribution to journalArticle

24 Scopus citations


Negative pressure wound therapy (NPWT) is frequently employed in the treatment of complex wounds. A variety of wound chemotherapeutic agents such as insulin, which acts as a growth factor, may prove helpful in treatment as well. We present a case report in which insulin was used as a chemotherapeutic agent in continuous-instillation NPWT. To our knowledge, this is the first report in the literature describing this method of delivery.

Original languageEnglish (US)
Pages (from-to)820-824
Number of pages5
JournalJournal of Diabetes Science and Technology
Issue number4
StatePublished - Jul 2010



  • Diabetic foot ulcers
  • Insulin
  • Negative pressure wound therapy
  • Wound chemotherapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering

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