NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang

Research output: Contribution to journalReview articlepeer-review

305 Scopus citations

Abstract

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

Original languageEnglish (US)
Pages (from-to)21-43
Number of pages23
JournalCancer Cell
Volume34
Issue number1
DOIs
StatePublished - Jul 9 2018

Keywords

  • KEAP1
  • NRF2
  • antioxidant response element (ARE)
  • cancer initiation and progression
  • carcinogenesis
  • chemoresistance
  • metabolic reprogramming
  • metastasis
  • oxidative stress

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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