NRF2 and the Hallmarks of Cancer

Montserrat Rojo de la Vega, Eli Chapman, Donna Zhang

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects. The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this Review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor promoting effects.

Original languageEnglish (US)
JournalCancer Cell
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Keywords

  • antioxidant response element (ARE)
  • cancer initiation and progression
  • carcinogenesis
  • chemoresistance
  • KEAP1
  • metabolic reprogramming
  • metastasis
  • NRF2
  • oxidative stress

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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