Nrf2 is crucial to graft survival in a rodent model of heart transplantation

Wei Wu, Quan Qiu, Huihui Wang, Samantha A. Whitman, Deyu Fang, Fangru Lian, Donna Zhang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Currently, the sole treatment option for patients with heart failure is transplantation. The battle of prolonging graft survival and modulating innate and adaptive immune responses is still being waged in the clinic and in research labs. The transcription factor Nrf2 controls major cell survival pathways and is central to moderating inflammation and immune responses. In this study the effect of Nrf2 levels in host recipient C57BL/6 mice on Balb/c allogeneic graft survival was examined. Importantly, Nrf2-/- recipient mice could not support the graft for longer than 7.5 days on average, whereas activation of Nrf2 by sulforaphane in Nrf2+/+ hosts prolonged graft survival to 13 days. Several immune cells in the spleen of recipient mice were unchanged; however, CD11b+ macrophages were significantly increased in Nrf2 -/- mice. In addition, IL-17 mRNA levels were elevated in grafts transplanted into Nrf2-/- mice. Although Nrf2 appears to play a crucial role in graft survival, the exact mechanism is yet to be fully understood.

Original languageEnglish (US)
Article number919313
JournalOxidative Medicine and Cellular Longevity
DOIs
StatePublished - 2013

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Transplantation (surgical)
Graft Survival
Heart Transplantation
Grafts
Rodentia
Transplants
Interleukin-17
Adaptive Immunity
Inbred C57BL Mouse
Innate Immunity
Cell Survival
Transcription Factors
Spleen
Heart Failure
Macrophages
Transplantation
Inflammation
Messenger RNA
Chemical activation
Cells

ASJC Scopus subject areas

  • Cell Biology
  • Aging
  • Biochemistry

Cite this

Nrf2 is crucial to graft survival in a rodent model of heart transplantation. / Wu, Wei; Qiu, Quan; Wang, Huihui; Whitman, Samantha A.; Fang, Deyu; Lian, Fangru; Zhang, Donna.

In: Oxidative Medicine and Cellular Longevity, 2013.

Research output: Contribution to journalArticle

Wu, Wei ; Qiu, Quan ; Wang, Huihui ; Whitman, Samantha A. ; Fang, Deyu ; Lian, Fangru ; Zhang, Donna. / Nrf2 is crucial to graft survival in a rodent model of heart transplantation. In: Oxidative Medicine and Cellular Longevity. 2013.
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