Nuclear factor kappa B (NF-κB): A novel cause for diabetes, coronary artery disease and cancer initiation and promotion?

Nathaniel S. Rial, Kwan Choi, Tam Nguyen, Branden Snyder, Marvin J. Slepian

Research output: Contribution to journalArticle

34 Scopus citations


Obesity is a growing epidemic in the United States (US). Obesity has been recognized as a modifiable risk factor for many diverse diseases including diabetes, cardiovascular disease and cancer burden. Common contributors to obesity include a high fat diet, smoking and physical inactivity. Systemic effects of obesity include increased micro-inflammatory molecules such as nuclear factor kappa B (NF-κB) that influence the both endothelial and epithelial layers as well as the supportive stroma. An emerging risk factor for micro-inflammation also includes periodontal disease. These pro-inflammatory states are hypothesized to contribute to diabetes as well as cardiovascular disease and cancer through the direct activation of NF-κB. Therefore, a comprehensive health care strategy would include reduction of diabetes, cardiovascular and cancer risk through the decrease in micro-inflammation.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalMedical Hypotheses
Issue number1
StatePublished - Jan 1 2012


ASJC Scopus subject areas

  • Medicine(all)

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