Nuclear Genes Involved in Mitochondrial Function and Biogenesis

A. Tzagoloff, Carol L Dieckmann

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mitochondria are subcellular organelles of eukaryotic cells responsible for conserving and converting the bulk of energy released during the oxidation of foodstuffs into ATP, the universal currency of biological energy. This organelle is the modern-day remnant of free-living bacteria that invaded and established themselves in a primitive nucleated cell with a less efficient mode of energy metabolism. Many genes of the invading bacteria have been lost but a substantial number were transferred to the nucleus of the host and only a few are still present in mitochondria. This article summarizes current knowledge about the PET genes that were incorporated during evolution into the host's genome and are now essential for maintaining the functional and structural intactness of mitochondria.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages306-309
Number of pages4
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

Keywords

  • ATP synthase
  • Biogenesis
  • Electron transfer complexes
  • Endosymbiont hypothesis
  • Mitochondria
  • Mitochondrial DNA
  • Oxidative phosphorylation
  • PET genes
  • Pet mutant
  • Respiration
  • Rho zero mutant
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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