Nuclear, optical, and magnetic resonance imaging in a mouse mammary window chamber model

Hui Min Leung, Rachel Schafer, Arthur F. Gmitro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An orthotopic mouse mammary window chamber (MWC) model has been developed for multimodal in-vivo functional and anatomical imaging of breast cancer xenografts. Capabilities to image numerous physiological aspects of the same tumor microenvironment over time has important applications such as in experiments studying the efficacies of therapeutic interventions, improvement of cancer detection and investigating basic cancer biology. The compatibility of this MWC model with optical, nuclear and magnetic resonance imaging (MRI) makes it possible to perform a multitude of studies ranging from cellular imaging to whole body imaging. Thus, the MWC represents a powerful tool for breast cancer research. Here, two imaging applications are highlighted, namely the nuclear imaging of glycolytic metabolism with 18FFDG and MRI of tissue perfusion. Nuclear imaging is performed with the use of a 3μm thin phosphor scintillator placed directly in contact with the tissue and visible light from the scintillation is directly detected in a low noise, light tight imaging system. Tissue perfusion is imaged either qualitatively with a dynamic contrast enhancement (DCE) MRI technique or quantitatively with an arterial spin labeling flow-sensitive alternating inversion recovery-rapid acquisition with relaxation enhancement (FAIR-RARE) technique.

Original languageEnglish (US)
Title of host publicationMedical Applications of Radiation Detectors IV
EditorsHans N. Roehrig, Lars R. Furenlid, H. Bradford Barber
PublisherSPIE
ISBN (Electronic)9781628412413
DOIs
StatePublished - Jan 1 2014
EventMedical Applications of Radiation Detectors IV - San Diego, United States
Duration: Aug 18 2014Aug 21 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9214
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherMedical Applications of Radiation Detectors IV
CountryUnited States
CitySan Diego
Period8/18/148/21/14

Keywords

  • Breast cancer
  • Glycolytic metabolism
  • Magnetic resonance imaging
  • Mammary window chamber
  • Multimodal imaging
  • Nuclear imaging
  • Scintillation
  • Tissue perfusion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Leung, H. M., Schafer, R., & Gmitro, A. F. (2014). Nuclear, optical, and magnetic resonance imaging in a mouse mammary window chamber model. In H. N. Roehrig, L. R. Furenlid, & H. B. Barber (Eds.), Medical Applications of Radiation Detectors IV [92140C] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 9214). SPIE. https://doi.org/10.1117/12.2065910