Nuclear receptors and epigenetic regulation

Ornella I. Selmin, Alberto P.G. Romagnolo, Donato F. Romagnolo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The activity of nuclear receptor (NR) at target genes is regulated by the interaction with ligands, coactivators, corepressors, DNA, and histone-modifying proteins. These interactions influence chromatin status and transcription of genes encoding for factors that impinge on breast cancer processes such as cell proliferation, invasion and metastasis, DNA repair, and differentiation. Epigenetic mechanisms such as DNA methylation at CpG islands and histone modifications influence transcriptional activity directed by various NR including the estrogen, progesterone, aromatic hydrocarbon, vitamin D, and retinoic X receptor. In breast tissues, dietary compounds may alter cancer risk through agonistic and antagonistic interactions toward one or more NR. Examples of food ligands for NR include resveratrol, genistein, curcumin, vitamin D, and omega-3 fatty acids. Based on the information that ~80% of breast cancer cases are sporadic, i.e., lack a hereditary origin, studies that focus on the interaction of specific or combinations of food compounds with NR promise to unravel new epigenetic strategies against breast cancer.

Original languageEnglish (US)
Title of host publicationHandbook of Nutrition, Diet, and Epigenetics
PublisherSpringer International Publishing
Pages1039-1065
Number of pages27
Volume2
ISBN (Electronic)9783319555300
ISBN (Print)9783319555294
DOIs
StatePublished - Jan 5 2019

Keywords

  • Breast cancer prevention
  • DNA methylation
  • Dietary ligands
  • Epigenetics
  • Histone modification
  • Nuclear receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Selmin, O. I., Romagnolo, A. P. G., & Romagnolo, D. F. (2019). Nuclear receptors and epigenetic regulation. In Handbook of Nutrition, Diet, and Epigenetics (Vol. 2, pp. 1039-1065). Springer International Publishing. https://doi.org/10.1007/978-3-319-55530-0_121